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AMG-51

AMG-51 Struktur
890019-63-3
CAS-Nr.
890019-63-3
Englisch Name:
AMG-51
Synonyma:
AMG-51;AMG-51 (KRC547);2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one;5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one;4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-
CBNumber:
CB42621126
Summenformel:
C34H33F2N5O5
Molgewicht:
629.65
MOL-Datei:
890019-63-3.mol

AMG-51 Eigenschaften

Siedepunkt:
739.7±70.0 °C(Predicted)
Dichte
1.33±0.1 g/cm3(Predicted)
pka
7.01±0.10(Predicted)

Sicherheit

AMG-51 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This protein kinase inhibitor (FW = 629.65 g/mol; CAS 890019-63-3; Solubility: 15 mM in DMSO), also known as 5-(3-fluoro-4-(6-methoxy-7- (3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one, targets c-Met, or hepatocyte growth factor receptor (HGFR), a protein tyrosine kinase that plays a key role in several cellular processes and is overexpressed or mutated in different human cancers. AMG-51 shows the enzyme selectivity of c-Met with a (Ki = 4.9 nM), with off-targets, such as IGFR (Ki = 22nM), Ron or Recepteur d'Origine Nantais kinase (Ki = 28nM), and KDR (Ki = 139 nM).

AMG-51 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AMG-51 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 11)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
SYN|thesis med chem P/L +86-021-50720296
service@synkinase.com China 266 58
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921
sales@pharmacodia.com China 2317 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Zhongshan Geometric Biological Technology Co., Ltd. +86-13168912896
China 253 58
Lynnchem 86-(0)29-85992781 17792393971
 info@lynnchem.com China 4587 58
Novachemistry 44-20819178-90 02081917890
 info@novachemistry.com United Kingdom 4381 58
Shanghai Biopharmaleader Co., Ltd. +86 18721201413
sales@biopharmaleader.com China 1720 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58
  • AMG-51
  • 5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one
  • 2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one
  • AMG-51 (KRC547)
  • 4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-
  • 890019-63-3
  • C34H33F2N5O5
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