5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
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- CAS-Nr.
- 30389-33-4
- Englisch Name:
- 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
- Synonyma:
- 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one;5-Hydroxy-3,4-dihydrocarbostyryl;Carteolol EP Impurity B;5-HYDROXY-3;Carteolol int;Carteolol Impurity 2;Carteolol Intermediate;Aripiprazole impurity 7;Aripiprazole Impurity 14;Brexpiprazole Impurity 70
- CBNumber:
- CB4259600
- Summenformel:
- C9H9NO2
- Molgewicht:
- 163.17
- MOL-Datei:
- 30389-33-4.mol
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5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Eigenschaften
- Schmelzpunkt:
- 225-227°C
- Siedepunkt:
- 381.2±42.0 °C(Predicted)
- Dichte
- 1.282±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 9.63±0.20(Predicted)
- Farbe
- White to Off-White
- InChI
- InChI=1S/C9H9NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-3,11H,4-5H2,(H,10,12)
- InChIKey
- UTTJAIFHRUAFED-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(O)=CC=C2)CCC1=O
- CAS Datenbank
- 30389-33-4(CAS DataBase Reference)
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-white Solid
Verwenden
Carteolol (C184450) metabolite.
Synthese
To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 213)Lieferanten
30389-33-4()Verwandte Suche:
- 3,4-DIHYDRO-5-HYDROXY-2(1H)-QUINOLINONE
- 5-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
- 5-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE
- 3,4-Dihydro-5-hydroxycarbostyril
- 5-HYDROXY-3,4-DIHYDRO-2-QUINOLINE
- 5-Hydroxy-2(1H)-3,4-dihydroquinolinone
- 3,4-Dihydro-5-hydroxy-1H-quinolin-2-one
- 5-Hydroxy-3,4-dihydrocarbostyril
- 3,4-Dihydro-5-hydroxyquinolin-2(1H)-one
- 5-Hydroxy-1,2,3,4-tetrahydroquinoline-2-one
- 5-hydroxy-1,2,3,4-tetrahydro-2-quinolinone
- 5-hydroxy-1,2,3,4-tetrahydroquinolin-2-one
- 2(1H)-Quinolinone, 3,4-dihydro-5-hydroxy-
- Carteolol HCl EP Impurity B
- Carbostyril,3,4-dihydro-5-hydroxy- (8CI)
- Aripiprazole Impurity 14
- Carteolol Intermediate
- 5-Hydroxy-3,4-dihydroquinolin-2(1H)
- Carteolol Impurity 2
- Aripiprazole impurities1768
- 5-hydroxy-3,4-dihydro-1-h-quinoline
- 5-HYDROXY-3
- 4-DIHYDRO-1H-QUINOLIN-2-ONE
- 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one(For export only)
- 5-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline
- Carteolol Hydrochloride impurity B
- Aripiprazole impurity 7
- Brexpiprazole Impurity 70
- Carteolol int
- 5-Hydroxy-3,4-dihydrocarbostyryl
- 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
- Carteolol EP Impurity B
- Carteolol EP Impurity B（Aripiprazole Impurity 26）
- 5-Hydroxy-3,4-dihydro-2(1H)-quinolinone (5-HQ)
- 5-Hydroxy-3,4-dihydro-2(1h)-
quinolinone, 98% (Custom work)
- 30389-33-4
- pharmacetical
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- API
