COX Fluorescent Inhibitor Screening Assay Kit Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG₂), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH₂), the precursor of PGs, thromboxanes, and prostacyclins. It is now well established that there are two distinct isoforms of COX, COX-1 and COX-2. Cayman’s COX Fluorescent Inhibitor Screening Assay provides a convenient fluorescence-based method for screening ovine COX-1 and human recombinant COX-2 for isozyme-specific inhibitors. The assay utilizes the peroxidase component of COXs. In this assay, the reaction between PGG₂ and ADHP (10-acetyl-3,7-dihydroxyphenoxazine) produces the highly fluorescent compound resorufin. Resorufin fluorescence can be analyzed with an excitation wavelength of 530-540 nm and an emission wavelength of 585-595 nm.

COX Fluorescent Inhibitor Screening Assay Kit Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

COX Fluorescent Inhibitor Screening Assay Kit Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Cayman Chemical Company	--	cayman@caymanchem.com	United States	6213	81

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• COX Fluorescent Inhibitor Screening Assay Kit