25-hydroxy Cholesterol-d6
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- CAS-Nr.
- 88247-69-2
- Englisch Name:
- 25-hydroxy Cholesterol-d6
- Synonyma:
- 25-hydroxy Cholesterol-d6;cholest-5-ene-3,25-diol-d6;cholest-5-ene-3β,25-diol-d6;CHOLEST-5-ENE-3,25-DIOL-D6;25-HYDROXYCHOLESTEROL-D6;(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
- CBNumber:
- CB42589994
- Summenformel:
- C27H40D6O2
- Molgewicht:
- 408.689910668
- MOL-Datei:
- 88247-69-2.mol
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25-hydroxy Cholesterol-d6 Eigenschaften
- Schmelzpunkt:
- >155°C (dec.)
- storage temp.
- -20°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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25-hydroxy Cholesterol-d6 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.
Allgemeine Beschreibung
25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol.
Biochem/physiol Actions
25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase. It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition.
25-hydroxy Cholesterol-d6 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
25-hydroxy Cholesterol-d6 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 38)Lieferanten
- 25-hydroxy Cholesterol-d6
- cholest-5-ene-3,25-diol-d6
- CHOLEST-5-ENE-3,25-DIOL-D6;25-HYDROXYCHOLESTEROL-D6
- (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
- cholest-5-ene-3β,25-diol-d6
- 88247-69-2
- C27H40D6O2
