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CEP-18770

CEP-18770 Struktur
847499-27-8
CAS-Nr.
847499-27-8
Englisch Name:
CEP-18770
Synonyma:
CS-252;CT 47098;CEP-18770;CIP 18770;NPH 007098;Delanzomib;Delanzomib, >=98%;CEP-18770 (DelanzoMib);DelanzoMib (CEP-18770);DelanzoMib, Free Base, >99%
CBNumber:
CB42570998
Summenformel:
C21H28BN3O5
Molgewicht:
413.28
MOL-Datei:
847499-27-8.mol

CEP-18770 Eigenschaften

Schmelzpunkt:
178-190°C (dec.)
Dichte
1.207
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
L?slichkeit
Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
9.67±0.43(Predicted)
Farbe
White to Off-White
Stabilit?t:
Hygroscopic

Sicherheit

HS Code  29333990

CEP-18770 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC50 = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity. Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC50s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis.

Verwenden

Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.

CEP-18770 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CEP-18770 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 119)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Win-Win chemical CO., Limited
+86-0086-577-64498589 +86-15355981851
sales@win-winchemical.com China 14426 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58

  • CEP-18770
  • [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid
  • CIP 18770
  • CT 47098
  • Delanzomib
  • NPH 007098
  • CEP-18770 (DelanzoMib)
  • DelanzoMib, Free Base, >99%
  • ((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinaMido)butanaMido)-3-Methylbutyl)boronic acid
  • (R)-1-((2S,3R)-3-hydroxy-2-(2-phenylpicolinamido)butanamido)-3-methylbutan-2-ylboronic acid
  • Delanzomib [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid
  • Delanzomib, >=98%
  • DelanzoMib (CEP-18770)
  • Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]aMino]butyl]aMino]-3-Methylbutyl]-
  • (1R)-1-[(2S,3R)-3-hydroxy-2-[(6-phenylpyridin-2-yl)formamido]butanamido]-3-methylbutyl]boronic acid
  • CS-252
  • CEP-18770;CEP 18770;CEP18770
  • ((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutan-2-yl)boronic acid
  • 847499-27-8
  • C21H28BN3O5
  • Inhibitor
  • Inhibitors
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