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Prucalopride Succinate

Prucalopride Succinate Struktur
179474-85-2
CAS-Nr.
179474-85-2
Englisch Name:
Prucalopride Succinate
Synonyma:
R-108512;RESOLOR; R-108512;Resolor Succinate;PRUCALOPRIDE SUCCITE;Prucalopride Impurity;Prucalopride Succinat;Priucapride succinate;Prucalopride Succinate;Prucalopride Succinate WS;PRUCALOPRIDE INTERMEDIATES
CBNumber:
CB42510031
Summenformel:
C22H32ClN3O7
Molgewicht:
485.96
MOL-Datei:
179474-85-2.mol

Prucalopride Succinate Eigenschaften

Schmelzpunkt:
>196°C (dec.)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Pale Brown
InChIKey
QZRSNVSQLGRAID-UHFFFAOYSA-N
SMILES
C(O)(=O)CCC(O)=O.O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H412 Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 3 P273, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P273 Freisetzung in die Umwelt vermeiden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Prucalopride Succinate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is Off-White to Pale Brown Solid

Verwenden

Prucalopride Succinate is the succinate form of prucalopride. It is a selective 5-HT4 receptor agonist used for the treatment of chronic constipation in adults for whom laxatives are not effective. It is not indicated for use in children and adolescents under 18 years of age.

Mechanism of action

The succinate form of prucalopride is an orally bioavailable dihydrobenzofurancarboxamide and selective serotonin (5-HT4) receptor agonist with pro-gastrointestinal motility activity. Upon oral administration, procalcitonin specifically targets, binds and stimulates 5-HT4 receptors. This alters the pattern of colonic motility and stimulates large amounts of peristalsis in the colon. This normalises bowel movements and relieves chronic constipation. In addition, by increasing peristalsis in the oesophagus and stomach, prucalopride also relieves symptoms associated with inhalation.

Clinical Use

Prucalopride succinate, a first-in-class dihydrobenzofurancarboxamide, is a selective serotonin (5- HT4) receptor agonist. The drug, marketed under the brand name Resolor®, possesses enterokinetic activity and was developed by the Belgian-based pharmaceutical firm Movetis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation, triggering the central propulsive force for defecation.

Nebenwirkungen

The most common adverse reactions to Prucalopride Succinate include: headache, nausea, diarrhoea and abdominal pain, loss of appetite, dizziness, vomiting, digestive disturbances (dyspepsia), windiness, abnormal bowel sounds, and tiredness. Other side effects that may come out below are: tremor, rapid heartbeat, rectal bleeding, increased urination (pollenuria), fever, overall general feeling of malaise, flatulence. Severe allergic reactions are rare and manifest as hives or lumps, itching, rash,redness of the skin, facial swelling, and chest tightness. Contact your doctor if any of these serious adverse reactions occur.

Prucalopride Succinate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prucalopride Succinate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 258)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Innopharm Industrial Co., Ltd.
+86-21-59960785 +86-17701845089
sales@hoyaopharm.com China 338 58
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
+86-0551-68665055 +86-+86-18616906106
sales@trywchem.com China 148 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
sean.lv@synzest.com China 323 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 1010 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 484 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29793 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29879 58

179474-85-2()Verwandte Suche:


  • Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
  • Prucalopride Succinate
  • Prucalopride Succinate API
  • PRUCALOPRIDE INTERMEDIATES
  • Prucalopride Succinat
  • Prucalopride Succinate WS
  • Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)
  • Prucalopride Impurity
  • R-108512
  • RESOLOR; R-108512
  • 7-cyclopenta[b]pyrancarboxamide
  • 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic acid
  • 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate
  • 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide Butanedioic Acid
  • Prucalopride succinate, 98.5%, a selective high affinity 5-HT4 receptor agonist
  • Resolor Succinate
  • Prucalopride Succinate USP/EP/BP
  • Prucalopride Succinate (R-108512, R-93877)
  • Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methox...
  • Prucalopride Succinate 13CD3Q: What is Prucalopride Succinate 13CD3 Q: What is the CAS Number of Prucalopride Succinate 13CD3
  • TIANFU-CHEM - Prucalopride Succinate
  • 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioicaci
  • PRUCALOPRIDE SUCCITE
  • Prucalopride Succinate 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3 -dihydrobenzofuran-7-carboxamide succinate
  • Priucapride succinate
  • 179474-85-2
  • C18H26ClN3O3C4H6O4
  • C22H32N3O7Cl
  • Inhibitors
  • API
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