Rpaf-ah
|
|
|
- CAS-Nr.
- 208576-22-1
- Englisch Name:
- Rpaf-ah
- Synonyma:
- Pafase;Rpaf-ah;Epafipase;PAF-AH human;PAF 2-acylhydrolase;Paf acetylhydrolase;Epafipase [usan:inn];LDL-associated phospholipase A2;Deacetylase, 1-alkyl-2-acetyllecithin (human);2-acetyl-1-alkylglycerophosphocholine esterase
- CBNumber:
- CB42493219
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
|
Rpaf-ah Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- lyophilized
- Farbe
- white
Rpaf-ah Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Antiallergenic;
antiasthmatic (PAF antagonist [PAF acetylhydrolasemphor.].
Allgemeine Beschreibung
Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55kDa by SDS-PAGE analysis.
Biochem/physiol Actions
Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet activating factor acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL (low density lipoprotein) particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. High levels of PAF-AH in plasma can be an indication of resistant hypertension. Polymorphism in PAF-AH gene at A379V might be linked with ischemic stroke susceptibility.
Rpaf-ah Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rpaf-ah Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 5)Lieferanten
- 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine deacetylase-(6-400)-peptide (human)
- Deacetylase, 1-alkyl-2-acetyllecithin (human)
- Epafipase
- Epafipase [usan:inn]
- Paf acetylhydrolase
- Pafase
- Rpaf-ah
- 2-acetyl-1-alkylglycerophosphocholine esterase
- LDL-associated phospholipase A2
- PAF 2-acylhydrolase
- PAF-AH human
- 208576-22-1
