PSYCHOSINE
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- CAS-Nr.
- 2238-90-6
- Englisch Name:
- PSYCHOSINE
- Synonyma:
- PSYCHOSIN;PSYCHOSINE;PSYCHOSINE(RG);LYSO-CEREBROSIDE;PSYCHOSINE USP/EP/BP;Galactosylsphingosine;O-Galactosylsphingosine;Psychosine (free amine);Sphingosine galactoside;LYSO-CERAMIDEGALACTOSIDE
- CBNumber:
- CB4245038
- Summenformel:
- C24H47NO7
- Molgewicht:
- 461.63
- MOL-Datei:
- 2238-90-6.mol
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PSYCHOSINE Eigenschaften
- Schmelzpunkt:
- 190 °C (decomp)
- Siedepunkt:
- 664.3±55.0 °C(Predicted)
- Dichte
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Chloroform/Methanol/DI water (5:1:0.1): soluble; Ethanol: soluble
- Aggregatzustand
- lyophilized powder
- pka
- 11.74±0.45(Predicted)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
20/21/22 |
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| S-S?tze: |
36 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P370+P378 |
Bei Brand: zum L?schen verwenden. |
| P403+P233 |
An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten. |
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PSYCHOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]
Verwenden
Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.
Definition
ChEBI: A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.
Allgemeine Beschreibung
Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.
Enzyminhibitor
This cationic brain lysosphingolipid (FWfree-base = 461.64 g/mol; CAS 2238- 90-6), also known as 1-O-b-D-galactosylsphingosine, inhibits metabotropic a1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. Psychosine also exerts protective effects against quisqualate, suggesting it may be useful in prophylaxis of neurodegenerative disorders arising from over-stimulation of hippocampal Group 1 metabolotropic glutamate receptor, or mGluR. Psychosine is the product of the reaction catalyzed by sphingosine b-galactosyltransferase and is the substrate for psychosine sulfotransferase and galactosylceramidase. Target(s): cerebroside-sulfatase, or arylsulfatase A; cytochrome c oxidase; cytokinesis; electron transport; galactosylgalactosylglucosylceramidase; glucocerebrosidase, lysosome; b-glucosidase; phosphorylase kinase; protein kinase C (11- 14); protein-tyrosine sulfotransferase; and sphingomyelinase.
PSYCHOSINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PSYCHOSINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
2238-90-6()Verwandte Suche:
- PSYCHOSINE
- 1-BETA-D-GALACTOSYLSPHINGOSINE
- 1-B-D-GALACTOSYLSPHINOGOSINE
- LYSO-CERAMIDEGALACTOSIDE
- LYSO-CEREBROSIDE
- D-GALACTOSYL-B1-1'-D-ERYTHRO-SPHINGOSINE
- D-GALACTOSYL-B1-1' SPHINGOSINE
- D-GALACTOSYL-B1-1' SPHINGOSN
- 1-β-d-galactosylsphingosine
- (2R,3R,4S,5S,6R)-2-[(E,2S,3R)-2-amino-3-hydroxy-octadec-4-enoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
- Galactosylsphingosine
- PSYCHOSINE(RG)
- (2S,3R,4E)-1-(β-D-Galactopyranosyloxy)-2-amino-4-octadecene-3-ol
- [(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecenyl]β-D-galactopyranoside
- 1-O-β-D-Galactopyranosylsphingosine
- O-Galactosylsphingosine
- PEONIDIN-3-O-GALACTOSIDE CHLORIDE(RG)
- D-galactosyl-1-1'-D-erythro-sphingosine
- Psychosine (Galactosylsphingosine)
- SPHINGOSYL-BETA-D-GALACTOPYRANOSIDE
- SPHINGOSINE, 1-BETA-D-GALACTOSYL
- PSYCHOSIN
- Galactosylsphingosine (d18:1)
- β-D-Galactopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl
- Galactosyl(beta) Sphingosine (d18:1)
- Psychosine Quantitative Mass Spec Standard
- PSYCHOSINE USP/EP/BP
- D-galactosyl-β1-1'-D-erythro-sphingosine
- Psychosine (free amine)
- b-D-Galactosylsphingosine - Synthetic
- Sphingosine galactoside
- Galactosylsphingosine (d18:1) (synthetic)
- D-galactosyl-β1-1'-D-erythro-sphingosine
- Galactosyl(β) Sphingosine (d18:1)
- 2238-90-6
- C24H47NO7
- BioChemical
- Metabolomics
- Metabolic Libraries
- Lipid Library
- Miscellaneous Natural Products
