Cryptotanshinone
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- CAS-Nr.
- 35825-57-1
- Englisch Name:
- Cryptotanshinone
- Synonyma:
- CRYPTOTANSHINONE;Cryptotanshinon;Cryptotanshinone, Tanshinone c;CS-1284;98% BY HPLC;Tanshinone c;Cryptotanshine;Noncrystalline;yindanshentong;Crypttanshinone
- CBNumber:
- CB4222031
- Summenformel:
- C19H20O3
- Molgewicht:
- 296.36
- MOL-Datei:
- 35825-57-1.mol
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Cryptotanshinone Eigenschaften
- Schmelzpunkt:
- 192°C(lit.)
- Siedepunkt:
- 459.0±45.0 °C(Predicted)
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥5mg/mL
- Aggregatzustand
- powder
- Farbe
- orange-brown
- Optische Aktivit?t
- [α]/D -85.0±3.0°, c = 0.1 in chloroform
- maximale Wellenl?nge (λmax)
- 263nm(lit.)
- BRN
- 5445400
- InChIKey
- IJSBKZLSTIFYIE-FPKDZHNTSA-N
- LogP
- 4.130 (est)
- CAS Datenbank
- 35825-57-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T,N |
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| R-S?tze: |
25-50/53 |
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| S-S?tze: |
45-60-61 |
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| RIDADR |
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
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| WGK Germany |
3 |
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| RTECS-Nr. |
SF8282645 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
29321900 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Cryptotanshinone Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Orange powder
Verwenden
inhibits angiogenesis
Allgemeine Beschreibung
Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of
Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr
705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats
in vivo (600 mg/kg/day).
Biologische Aktivit?t
Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.
Cytotoxicity
IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)
Cryptotanshinone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cryptotanshinone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 371)Lieferanten
35825-57-1()Verwandte Suche:
N,N,N',N',N'',N''-Hexamethyl-4,4',4''-methylidintrianilin
DL-Borneol
Vitamin-A-s?ure
Berberin
1,2-Naphthochinon
Trimethylcumol
1,2,3,4-Tetrahydro-1,5-dimethylnaphthalin
- 98% BY HPLC
- CRYPTOTANSHINONE >
- TANSHINONE, CRYPTO(P)
- (r)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione
- TANSHINONE, CRYPTO
- hexahydro-1,6,6-trimethyl-,(R)-
- Phenanthro[1,2-b]furan-10,11-dione,1,2,6,7,8,9-
- 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione
- Cryptotanshine
- Cryototanshinone
- Tanshinone c
- Phenanthro[1,2-b]furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (1R)-
- Cryptotanshinone
(R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione
- 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione
- Cryptotanshinone, froM Salvia Miltiorrhiza
- Phenanthro[1,2-b]furan-10,11-dione,1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (R)-
- Cryptotanshinone (Cryptotanshinon)
- Noncrystalline
- Crypttanshinone
- (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione USP/EP/BP
- Cryptotanshinone, 98%, from Salvia miltiorrhiza Bunge
- (1R)-1,6,6-trimethyl-2,3a,7,8,9,11a-hexahydro-1H-naphtho[1,2-g]benzofuran-10,11-dione
- Cryptotanshinone 35825-57-1
- Cryptotanshinone, 98%, from Salvia miltiorrhiza
- CS-1284
- Cryptotanshinone - CAS 35825-57-1 - Calbiochem
- CRYPTOTANSHINONE
- Cryptotanshinon
- Cryptotanshinone, Tanshinone c
- yindanshentong
- Cryptotanshinone POWDER
- Cryptotanshinon|||Tanshinone c
- Cryptotanshinone-RM
- Cryptotanshinone, STAT3 inhibitor
- 35825-57-1
- 35825-57-2
- Anthraquinones, Hydroquinones and Quinones
- The group of Danshen
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Herb extract
- Inhibitors
