D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P₁ and G_qi5, which allows for phospholipase C stimulation by G_i proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P₂ and S1P₃ receptors (EC₅₀s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.

Chemische Eigenschaften

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Definition

ChEBI: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1

Allgemeine Beschreibung

Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants. Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine and regulates S1P levels. It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.

Biologische Aktivit?t

Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors, S1P 1-5 . Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10319	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Nanjing Duly Biotech Co.,Ltd	+undefined18013301590	melody@njduly.com	China	2450	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58

26993-30-6()Verwandte Suche:

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• 1-SPP
• (E)-D-ERYTHRO-2-AMINO-1-(DIHYDROGENPHOSPHATE)-4-OCTADECENE-1,3-DIOL
• D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE
• D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
• SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO
• SPHINGOSINE-1-PHOSPHORIC ACID
• SPHINGOSINE-1-PO4
• SPN-1-P
• SHINGOSINE-1-PHOSPHATE \ EDG-1 RECEPTOR
• D-erythro-Sphingosine 1-phosphate,96%
• D-erythro-Sphingosin-1-phosphate
• 1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), D-erythro- (8C I)
• (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate
• (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid
• (2S,3R,4E)-2-AMino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate)
• (2S,3R,E)-2-aMino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
• 4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt
• (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
• Mouse Sphingosine-1-phosphate elisa kit
• 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-
• Sphingosine-1-phosphate (d18:1)
• D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem
• SPA
• SPHINGOSINE-1-PHOSPHATE
• S1P
• Quetiapine Impurity 54-d8
• D-erythro Sphingosine-1-phosphate, agonist of S1P receptors
• 26993-30-6
• C18H38NO5P
• proteins
• Chemical Activators
• Activators
• Fatty Acid Derivatives & Lipids
• Glycerols
• Inhibitors
• Protein Kinase Inhibitors and Activators
• Angiogenic FactorsSphingolipids
• Angiogenesis
• Cancer Research
• Lipids in Cell Signaling
• Sphingoid base 1-phosphatesCell Signaling and Neuroscience
• Sphingoid bases
• Sphingolipids
• Lysophospholipid receptor and related