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Sodium hyaluronate

Sodium hyaluronate Struktur
9067-32-7
CAS-Nr.
9067-32-7
Englisch Name:
Sodium hyaluronate
Synonyma:
hyaluronic;Hyaluronate;HYALURONIC ACID SODIUM;Sph;HYALURONIC ACID SODIUM SALT;Hyaluronesodium;Sodium Hyaluronic;3000 Da;HYALURONIC ACID NA-SALT;sodium hyaluronate powder
CBNumber:
CB4176691
Summenformel:
C14H22NNaO11
Molgewicht:
403.31
MOL-Datei:
9067-32-7.mol

Sodium hyaluronate Eigenschaften

Schmelzpunkt:
>209°C (dec.)
alpha 
D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951)
storage temp. 
-20°C
L?slichkeit
H2O: 5 mg/mL, clear, colorless
Aggregatzustand
Powder
Farbe
White to cream
PH
pH(2g/l,25℃) : 5.5~7.5
Wasserl?slichkeit
SOLUBLE
Merck 
13,4776
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
InChIKey
MAKUBRYLFHZREJ-JWBQXVCJSA-M
SMILES
[C@@H]1(O[C@H]2[C@H](O)[C@H]([C@H](O)O[C@@H]2C(=O)[O-])O)O[C@H](CO)[C@@H](O)C[C@H]1NC(=O)C.[Na+] |&1:0,2,3,5,6,9,15,18,21,r|
LogP
-6.623 (est)
CAS Datenbank
9067-32-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gef?hrlicher B,Xi
R-S?tze: 36/37/38
S-S?tze: 22-24/25-36/37/39-27-26
WGK Germany  3
RTECS-Nr. MT7250000
3-10
HS Code  39139000
Toxizit?t LD50 oral in rabbit: > 1gm/kg

Sodium hyaluronate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getr?nkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

The PhEur 6.3 describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic.

Verwenden

sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form.

Application

Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Sodium hyaluronate is widely used as follows:
antifungal agent.
prevents thromboembolic complications.
aldosterone antagonist used as an adjunct in the management of chronic heart failure.
suitable as substrate for hyaluronidase.
Surgical aid (ophthalmological).

Definition

Sodium Hyaluronate is a polysaccharide of linear and repeating structural units of the disaccharide D-glucuronic acid and N-acetylD-glucosamine. Hyaluronic acid in human body usually present as polymers with several million molecular weight, and the structural difference by the animal species has not been confirmed.

Vorbereitung Methode

Sodium hyaluronate occurs naturally in vitreous humor, serum, chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs. It may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration. It is then precipitated with an organic solvent and dried.

Pharmazeutische Anwendungen

Sodium hyaluronate is the predominant form of hyaluronic acid at physiological pH. The name hyaluronan is used when the polysaccharide is mentioned in general terms, and in the literature the terms hyaluronic acid and sodium hyaluronate are used interchangeably.
Hyaluronan is used therapeutically to treat osteoarthritis in the knee, and is an effective treatment for arthritic pain. Crosslinked hyaluronan gels are used as drug delivery systems.
Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.(4) This is useful for enhancing the availability and retention time of drugs administered to the eye. It is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery systems; it also has important applications in the fields of vascosurgery and vascosupplementation.

Sicherheit(Safety)

Sodium hyaluronate is used in cosmetics and in topical, parenteral, and ophthalmic pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material. Sodium hyaluronate has been reported to be an experimental teratogen.
LD50 (mouse, IP): 1.5 g/kg
LD50 (rabbit, IP): 1.82 g/kg
LD50 (rat, IP): 1.77 g/kg

Lager

Sodium hyaluronate should be stored in a cool, dry place in tightly sealed containers. The powder is stable for 3 years if stored in unopened containers.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical gel preparation).

Sodium hyaluronate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sodium hyaluronate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 712)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ZhenYiBio Technology Inc
+8615309206328
alexxue@zhenyibio.com China 296 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887
sales@finerchem.com China 2961 58
Wuhan Quanjinci New Material Co.,Ltd.
+86-15271838296; +8615271838296
kyra@quanjinci.com China 1512 58
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+8613343047651
admin@zlchemi.com China 3002 58
Shanghai Likang New Materials Co., Limited
+86-16631818819 +86-17736933208
3684455296@qq.com China 9300 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
SUZHOU NMT BIOTECH CO.,LTD
+8618012730781
sales2@nmtbiotech.com China 41 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58

9067-32-7()Verwandte Suche:


  • cockscomb
  • Si-4402
  • Sl-1010
  • HYALURONIC ACID SODIUM FROM*STREPTOCOCCU S ZOOEPIDEM
  • HYALURONIC ACID SODIUM SALT F. STREPTO-C OCCUS EQUI SP.
  • HYALURONIC ACID SODIUM FROM ROOSTER*COMB
  • β-Sodium glucuronate-(1,3)-β-N-acetyl-D-glucosamine
  • Hyaluronic acid-Na-salt from rooster comb
  • alternating copoly(β-glucuronic acid-[1→3]-β-n-acetylglucosamine-[1→4])
  • hyaluronic acid sodium salt from human umbilical cord
  • hyaluronic acid sodium salt from streptococcus zooepidemicus
  • SODIUMHYALURINATE
  • SODIUM HYALURONATE(TOPICAL GRADE)
  • Hyaluronic Acid Sodium Salt from Cockscomb
  • Chlamyhyaluronic acid sodium salt
  • Injection Grade SodiuM hyaluronate
  • Medical Grade SodiuM hyaluronate
  • Hyasis 850P
  • Sodium Hyaluronate(HA)
  • Hyaluronate Sodium [USAN:JAN]
  • Hyaluronic Acid Sodium Salt from Microorganism
  • HYALURONIC ACID - COSMETIC
  • HYALURONIC ACID - EYE DROP
  • HYALURONIC ACID - FOOD
  • HYALURONIC ACID - INJECTION
  • HYALURONIC ACID EYE DROPS
  • HYALURONIC ACID GRADE A ( HA-QSS )
  • HYALURONIC ACID GRADE B ( HA-Q )
  • HYALURONIC ACID HA-L510 PF
  • HYALURONIC ACID INJECTABLE
  • HYALURONIC ACID LMW
  • HYALURONIC ACID LOW ENDOTOXIN
  • HYALURONIC ACID LOW MOL (10,000)
  • SODIUM HYALURONATE 2% SOLUTION
  • SODIUM HYALURONATE COSMETIC GRADE HMW
  • SODIUM HYALURONATE COSMETIC GRADE MMW
  • SODIUM HYALURONATE INJECTABLE GRADE LMW
  • SODIUM HYALURONATE INTRAARTICULAR GRADE HMW
  • SODIUM HYALURONATE OPHTHALMIC GRADE HMW
  • SODIUM HYALURONATE OPHTHALMIC GRADE LMW
  • SODIUM HYALURONATE OPHTHALMIC GRADE MMW
  • SODIUM HYALURONATE PHARMACEUTICAL GRADE (HMW)
  • SODIUM HYALURONATE PHARMACEUTICAL GRADE (LMW)
  • SODIUM HYALURONATE PHARMACEUTICAL GRADE (MMW)
  • HYALURONIC ACID SODIUM SALT 2,000,00
  • HYALURONIC ACID SODIUM SALT 8,000-15
  • HYALURONIC ACID SODIUM SALT FROM ROO
  • HYALURONIC ACID SODIUM SALT FROM STR
  • Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating Sodium hyaluronate
  • SODIUM HYALURONATE (STREPTOCOCCUS)
  • SODIUM HYALURONATE
  • POLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4]), ALTERNATING
  • Sodium Hyaluronate Injection Grade PH5.0
  • Sodium hyaluronate,95%
  • HYALURONIC ACID SODIUM FROM HUMAN UMBILICAL CORD
  • Sodium hyaluronate, Poly(β-glucuronic acid-[1-3]-β-N-acetylglucosamine-[1-4]) alternating
  • Sodium hyaluronate,transparence
  • Alternating copoly(beta-glucuronic acid-[1->3]-beta-N-acetylglucosamine-[1->4])
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