(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion
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- CAS-Nr.
- 2873-36-1
- Bezeichnung:
- (3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion
- Englisch Name:
- CYCLO(-LEU-PRO)
- Synonyma:
- gancidinw;Maculosin 6;Cyclo(Pro-Leu);CYCLO(-LEU-PRO);cyclo-l-leu-l-pro;Cyclo(L-Pro-D-Leu);Cyclo(L-Pro-L-Leu-);Cyclo(proline-leucine);Cyclo-L-prolyl-L-leucine;L-Leucyl-L-prolyl lactaM
- CBNumber:
- CB4142038
- Summenformel:
- C11H18N2O2
- Molgewicht:
- 210.27
- MOL-Datei:
- 2873-36-1.mol
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(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Eigenschaften
- Schmelzpunkt:
- 163-165℃
- Siedepunkt:
- 427.6±34.0 °C(Predicted)
- Dichte
- 1.14
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 13.27±0.40(Predicted)
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Toxizit?t |
mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including
Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for
E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of
B. amphitrite larva with an EC
50 value of 0.15 mM.
Chemische Eigenschaften
White Solid
Verwenden
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 95)Lieferanten
2873-36-1((3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion)Verwandte Suche:
- 2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer
- 4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(
- cyclo-l-leu-l-pro
- gancidinw
- (3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione
- (3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
- (3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
- Cyclo(L-leucyl-L-prolyl-)
- CYCLO(-LEU-PRO)
- Cyclo(L-Pro-L-Leu-)
- 3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
- 3-isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone
- (3S-trans)-Hexahydro-3-(2-Methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione
- Cyclo(L-Pro-D-Leu)
- Cyclo(Pro-Leu)
- Cyclo(proline-leucine)
- Cyclo-L-prolyl-L-leucine
- L-Leucyl-L-proline lactaM
- L-Leucyl-L-prolyl lactaM
- Maculosin 6
- (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
- Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-
- Cyclo(-L-Leu-L-Pro)≥ 99% (TLC)
- 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
- Cyclo(L-prolyl-L-leucyl)
- 2873-36-1
