ANTI-GRB2
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- CAS-Nr.
- Englisch Name:
- ANTI-GRB2
- Synonyma:
- ANTI-MI;Anti-bw;Anti-vit;Anti-ASH;ANTI-MITF;ANTI-GRB2;Protein Ash;Anti-MST084;Anti-Grb3-3;Anti-MSTP084
- CBNumber:
- CB4138446
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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ANTI-GRB2 Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- buffered aqueous solution
ANTI-GRB2 Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Mouse monoclonal clone C5 anti-Microphthalmia antibody is used to tag serine phosphorylated and non-phosphorylated melanocytic isoforms of microphthalmia for detection and quantitation by techniques such as immunoblotting (doublet of 52-56 kDa), immunoprecipitation, immunohistochemistry on formalin-fixed paraffin embedded or frozen tissue sections, and gel shift. It is used as a probe to determine the roles of microphthalmia in the differentiation, development and survival of melanocytes and cells of the retinal pigment epithelium.
Allgemeine Beschreibung
Microphthalmia (Mi in mouse or MITF in human) is a basic helix-loop-helix-leucine zipper (BHLH–ZIP) transcription factor involved in the differentiation, development and survival of melanocytes and cells of the retinal pigment epithelium, i.e. cells responsible for hair, skin, and eye color. It activates the expression of the melanocyte specific genes tyrosinase and TRP1 (tyrosinase-related protein 1) by binding as a homo- or heterodimer to a symmetrical DNA sequence (E box) (5′-CATGTG-3′) located within the M box found in their promoters. Microphthalmia also appears to be involved in the differentiation of mast cells, osteoclasts, basophils and natural killer cells.
Microphthalmia is expressed in a limited number of cell types including heart, mast cells, osteoclast precursors, and melanocytes. There are a number of different isoforms of microphthalmia resulting from alternative splicing and alternative promotors. These isoforms differ at their amino-termini and in their expression patterns.
ANTI-GRB2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ANTI-GRB2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 20)Lieferanten
- MONOCLONAL ANTI-MICROPHTHALMIA
- MICROPHTHALMIA (AB-1) MONOCLONAL ANTIBODY
- ANTI-ASH/GRB2
- ANTI-ASH/GRB-2, HUMAN
- ANTI-MICROPHTHALMIA (AB-1)
- ANTI-MICROPHTHALMIA (AB-1), HUMAN
- ANTI-MICROPHTHALMIA (AB-1) MOUSE MAB
- ANTI-MI
- ANTI-MI (AB-1), HUMAN
- ANTI-MI (AB-1) MOUSE MAB
- ANTI-MITF
- ANTI-MITF (AB-1), HUMAN
- ANTI-MITF (AB-1) MOUSE MAB
- ANTI-GRB2
- ANTI-GRB2 (AB-2), HUMAN
- ANTI-HUMAN GRB2
- Monoclonal Anti-Grb-2 antibody produced in mouse
- Monoclonal Anti-Microphthalmia antibody produced in mouse
- Anti-GRB2 antibody produced in chicken
- Adapter protein GRB2
- Anti-GRB2 antibody produced in rabbit
- Protein Ash
- SH2/SH3 adapter GRB2
- Anti-MST084
- Anti-MSTP084
- Anti-bw
- Anti-MGC124309
- Anti-MGC124310
- Anti-vit
- Anti-ASH
- Anti-EGFRBP-GRB2
- Anti-GRB2 antibody produced in goat
- Anti-Grb3-3
- Anti-Growth factor receptor-bound protein 2
- GAntibodies for Kinase/Phosphatase Biology
- Grb-2
- Receptor Tyrosine Kinase Adaptor Protein Antibodies
- Alphabetical Index
- Antibodies
- Clone Index
- GAntibodies
