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zerumbone

zerumbone Struktur
471-05-6
CAS-Nr.
471-05-6
Englisch Name:
zerumbone
Synonyma:
zerumbone;Zerumbone-RM;ZeruMbone (6CI,7CI);Zingiber zerumbe extract;GIHNTRQPEMKFKO-SKTNYSRSSA-N;(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienone;(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one;(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one;2,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (2E,6E,10E)-
CBNumber:
CB41346756
Summenformel:
C15H22O
Molgewicht:
218.33
MOL-Datei:
471-05-6.mol

zerumbone Eigenschaften

Schmelzpunkt:
67-69℃
Siedepunkt:
321.6±42.0 °C(Predicted)
Dichte
0.887±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥10mg/mL
Aggregatzustand
powder
Farbe
white to off-white
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP
4.168 (est)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,N
R-S?tze: 43-50
S-S?tze: 36/37-60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

zerumbone Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Zerumbone has been used:
  • for liquid chromatography with mass spectrometry (LC-MS-MS)
  • to investigate its potential application in the prevention
  • treatment of esophageal squamous cell carcinomas (ESCC)

Definition

ChEBI: A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillati n from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.

Allgemeine Beschreibung

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Anticancer Research

Zerumbone is isolated from the rhizomes of the wild ginger Zingiber zerumbet. It isfound to suppress the proliferation of breast cancer and colon cancer cells and alsoto prevent initiation and promotion of skin cancer in mice. It also suppresses theNF-κB activation and its sequential suppression of IκBα kinase activity, IκBαphosphorylation, IκBα degradation, p65 phosphorylation, nuclear translocation,and acylation. It downregulates the NF-κB-regulated gene products like FLIP, cyclinD1, TRAF1, COX2, Bfl-1/A1, MMP-9, Bcl-xL, ICAM-1, Bcl-2, c-myc, XIAP,survivin, IAP1, and IAP2, and thus, it potentiates apoptosis (Murakami et al. 2002;Sakinah et al. 2007).

zerumbone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


zerumbone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 118)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Aktin Chemicals, Inc.
028-85159085
info@aktinchem.com CHINA 1025 58
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +86-18374838656
info@staherb.cn China 1025 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58

471-05-6()Verwandte Suche:


  • zerumbone
  • (2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one
  • ZeruMbone (6CI,7CI)
  • (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one
  • GIHNTRQPEMKFKO-SKTNYSRSSA-N
  • 2,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (2E,6E,10E)-
  • Zingiber zerumbe extract
  • (2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienone
  • Zerumbone-RM
  • 471-05-6
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