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Lexithromycin

Lexithromycin Struktur
53066-26-5
CAS-Nr.
53066-26-5
Englisch Name:
Lexithromycin
Synonyma:
Wy 48314;Lexithromycin;Erythromycin A-E-oxime;Azithromycin Impurity 4;Azithromycin Impurity 31;erythromycin A methoxime;Erythromycin A 9-Methoxime;Erythromycin, 9-(O-methyloxime);9-(Methoxyimino)-9-deoxoerythromycin;ErythroMycin A 9-MethoxiMe, Wy 48314
CBNumber:
CB41327717
Summenformel:
C38H70N2O13
Molgewicht:
762.97
MOL-Datei:
53066-26-5.mol

Lexithromycin Eigenschaften

Schmelzpunkt:
>115°C (dec.)
Siedepunkt:
824.6±75.0 °C(Predicted)
Dichte
1.26±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
L?slichkeit
Chloroform (Slightly), DMSO (Slightly)
pka
13.19±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Stabilit?t:
Hygroscopic

Sicherheit

Lexithromycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Lexithromycin is a semisynthetic antibiotic derived from erythromycin . Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability. As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel. Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.

Verwenden

Lexithromycin is an early semi-synthetic erythromycin, prepared by reaction of the 9-keto moiety to methyl oxime. The structural change improves the pH stability profile and hydrophobicity of lexithromycin for better in vivo absorption. This same rationale was used to greater effect with roxithromycin and, as a result, lexithromycin was quickly superseded and has not been not extensively studied. Like all tetracyclines, lexithromycin shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Lexithromycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Lexithromycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 44)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19741 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11922 58
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9460 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412
3001272453@qq.com China 5047 50
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18070 56
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656
greensnown@163.com China 9906 50

  • erythromycin A methoxime
  • 9-(Methoxyimino)-9-deoxoerythromycin
  • 9-Deoxo-9-[[methyloxy]imino]erythromycin
  • ErythroMycin A 9-MethoxiMe, Wy 48314
  • Erythromycin A-E-oxime
  • Erythromycin A-E-oxime LEXITHROMYCIN.
  • Lexithromycin
  • Erythromycin A 9-Methoxime
  • Azithromycin Impurity 4
  • Azithromycin Impurity 31
  • Wy 48314
  • Erythromycin, 9-(O-methyloxime)
  • 53066-26-5
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