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Rifamid

rifamide Struktur
2750-76-7
CAS-Nr.
2750-76-7
Bezeichnung:
Rifamid
Englisch Name:
rifamide
Synonyma:
M/14;rifamide;Rifomide;Rifamycin M-14;Rifomycin M-14;rifamide USP/EP/BP;Rifamycin B diethylamide;Rifomycin B diethylamide;Rifamycin, 4-O-[2-(diethylamino)-2-oxoethyl]-
CBNumber:
CB3908402
Summenformel:
C43H58N2O13
Molgewicht:
810.93
MOL-Datei:
2750-76-7.mol

Rifamid Eigenschaften

Schmelzpunkt:
170°C (rough estimate)
Siedepunkt:
755.63°C (rough estimate)
alpha 
D20 -48.7° (c = 0.4 in methanol)
Dichte
1.1791 (rough estimate)
Brechungsindex
1.4670 (estimate)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Toxizit?t LD50 in mice, rats (mg/kg): 2450, >4000 orally; 640, 2500 s.c.; 320, 535 i.p.; 315, 380 i.v. (Dezulian)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Rifamid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Antibacterial.

Pharmazeutische Anwendungen

The diethyl amide of rifamycin B, formulated as the sodium salt for parenteral administration. It exhibits high activity against Gram-positive organisms and M. tuberculosis typical of the group. MICs for Gram-negative bacilli are of the order of 20–50 mg/L.
It is absorbed orally and is rapidly eliminated through the bile, achieving concentrations sufficient to inhibit Gramnegative bacilli. In contrast to rifampicin, it can be administered as the sodium salt by intramuscular injection. A dose of 150 mg produces mean plasma levels of about 1 mg/L. The plasma halflife is about 2 h. The same dosage produces concentrations over 1 g/L in bile and c. 40 mg/L in the gallbladder wall.
Toxicity and side effects are similar to those of other rifamycins. It has been used in staphylococcal infections and infections of the biliary tract. It is unsuitable for the treatment of tuberculosis because of insufficient distribution to the tissues.

Rifamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Rifamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 22)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Wuhan Sunncell Biotech Co., Ltd. 17764018385
1242926414@qq.com China 1853 58
Shanghai Yaji Biological Technology Co., Ltd. 021-34661275 15301693058
yajikit@163.com China 9670 58
JENNIO-LAB(GUANGDONG) LIFE SCIENCE TECHNOLOGY CENTER 020-29185636 18802032712
2130357954@qq.com China 9791 58
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749
sales@shzbio.com China 9966 58
Guangzhou Fu'erbo Biological Technology Co.,Ltd. 19513720913
1536198927@qq.com China 9321 58
Shanghai Jingfeng Biotechnology Co., Ltd 17301805756 17301805756
69787182@qq.com China 7987 58

  • rifamide
  • M/14
  • Rifamycin B diethylamide
  • Rifamycin M-14
  • Rifomide
  • Rifomycin B diethylamide
  • Rifomycin M-14
  • Rifamycin, 4-O-[2-(diethylamino)-2-oxoethyl]-
  • rifamide USP/EP/BP
  • 2750-76-7
  • C43H58N2O13
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