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1-(5-Nitro-2-thiazolyl)-2-imidazolidinon

niridazole  Struktur
61-57-4
CAS-Nr.
61-57-4
Bezeichnung:
1-(5-Nitro-2-thiazolyl)-2-imidazolidinon
Englisch Name:
niridazole
Synonyma:
BA32644;Ambilhar;niridazole;NSC-136947;Nitrothiamidazole;1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE;1-(5-nitrothiazol-2-yl)imidazolidin-2-one;2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-;1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
CBNumber:
CB3896840
Summenformel:
C6H6N4O3S
Molgewicht:
214.204
MOL-Datei:
61-57-4.mol

1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Eigenschaften

Schmelzpunkt:
260-262°
Dichte
1.561 (estimate)
Brechungsindex
1.6200 (estimate)
Aggregatzustand
solid
pka
12.73±0.20(Predicted)
Farbe
Yellow crystals from DMF/MeOH
Wasserl?slichkeit
0.13g/L(25 ºC)
IARC
2B (Vol. 13, Sup 7) 1987
EPA chemische Informationen
Niridazole (61-57-4)

Sicherheit

Giftige Stoffe Daten 61-57-4(Hazardous Substances Data)
Toxizit?t TDLo orl-rat: 8 g/kg/90W-I:NEO CALEDQ 4,305,78 orl-rat LD50:900 mg/kg FAZMAE 17,108,73

1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Antischistosomal.

Pharmakologie

Niridazole exhibits schistosomicide and amebicidal action. The mechanism of action is not known. It seems likely that it is concentrated in the parasite organism, which causes inhibition of phosphorylase activation, which is expressed in the depletion of glycogen reserves.
It also may inhibit spermatogenesis of parasites by affecting the production of eggs. It is used for diseases caused by Dracunculus meddinesis, as well as Shistosoma haematobium and Shistosoma mansoni. It belongs to a group of tertiary drugs and is used only in the absence of the drug of choice. Synonyms of this drug are ambilhar and others.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent.

1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 9)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Alfa Chemistry 1-516-6625404
support@alfa-chemistry.com United States 9171 60
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772
huahero21@sina.com China 533 55
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 19704 58

61-57-4(1-(5-Nitro-2-thiazolyl)-2-imidazolidinon)Verwandte Suche:


  • niridazole
  • Ambilhar
  • BA32644
  • Nitrothiamidazole
  • NSC-136947
  • 1-(5-nitrothiazol-2-yl)imidazolidin-2-one
  • 1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE
  • 1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
  • 2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-
  • 61-57-4
  • C6H6N4O3S
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