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ILOPROST

ILOPROST Struktur
78919-13-8
CAS-Nr.
78919-13-8
Englisch Name:
ILOPROST
Synonyma:
zk36374;Ilomedin;LLOPROST;Endoprost;CILOPROST;Iloprost Na;iloprostaglandin;Iloprost (Ciloprost;1h)-pentalenylidene)-;(16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2)
CBNumber:
CB3775439
Summenformel:
C22H32O4
Molgewicht:
360.49
MOL-Datei:
78919-13-8.mol

ILOPROST Eigenschaften

Siedepunkt:
539.2±50.0 °C(Predicted)
Dichte
1.210±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Soluble in methyl acetate
pka
4.77±0.10(Predicted)
Aggregatzustand
film
Farbe
colorless
Stabilit?t:
Light Sensitive
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H311 Giftig bei Hautkontakt. Akute Toxizit?t dermal Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P280, P302+P352, P312, P322, P361,P363, P405, P501
H331 Giftig bei Einatmen. Akute Toxizit?t inhalativ Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P262 Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P403+P233 An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten.

ILOPROST Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Iloprost is a stable epoprostenol derivative which acts as an inhibitor of platelet aggregation and is recommended for the treatment of peripheral vascular diseases. The compound was shown to be a potent agonist at PGE2-sensitive and prostacyclin-sensitive receptors in animal studies. Iloprost is administered by IV infusion and has been reported to have beneficial effects in Buerger's and Raynaud's diseases as well as peripheral artery occlusive disease.

Chemische Eigenschaften

Colourless Oil

Definition

ChEBI: A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R /stereo>)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.

Health Hazard

Exposures to quinine vapor are highly irritating to the eyes and may be followed by corneal opacities, structural changes in the cornea, and loss of vision. Solid quinone may produce discoloration, severe irritation, swelling, and form papules and vesicles.

Biologische Aktivit?t

Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).

ILOPROST Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ILOPROST Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 144)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32002 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
86 18062405514 18062405514
ada@ipurechemical.com CHINA 3461 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244
mike_yan@xuanranglobal.com CHINA 4017 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58

  • (16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2)
  • 1h)-pentalenylidene)-
  • pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(
  • zk36374
  • 6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID
  • Endoprost
  • Ilomedin
  • (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoicacid
  • (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-Methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane
  • (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic Acid
  • Iloprost Na
  • Pentanoic acid,5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-Methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-,(5E)-
  • CILOPROST
  • 5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid
  • LLOPROST
  • iloprostaglandin
  • (E)-5-((3aS,4R,5R,6aS)-5-hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid
  • Iloprost (Ciloprost
  • 78919-13-8
  • Chiral Reagents
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • APIs
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