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6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat

Fenoldopam mesylate Struktur
67227-57-0
CAS-Nr.
67227-57-0
Bezeichnung:
6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat
Englisch Name:
Fenoldopam mesylate
Synonyma:
SKF R-82526;9CL-CORLOPAM;(S)-SKF-82526;(R)-SKF-82526;CORLOPAM MESYLATE;Fenodopam mesylate;SKF-82526 mesylate;FENOLDOPAM MESYLATE;FENOLDIPAM MESYLATE;FENOLDOPAM METHANESULFONATE
CBNumber:
CB3729841
Summenformel:
C17H20ClNO6S
Molgewicht:
401.86
MOL-Datei:
67227-57-0.mol

6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Eigenschaften

Schmelzpunkt:
274° (dec)
storage temp. 
room temp
L?slichkeit
DMSO: ≥15mg/mL at ~60°C
Aggregatzustand
powder
Farbe
white to tan
InChIKey
WOFIIEUMIDZJEJ-UHFFFAOYSA-N
CAS Datenbank
67227-57-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36-42/43
S-S?tze: 22-26-36/37/39
WGK Germany  3
HS Code  2933995300
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fenoldopam, first approved in the Netherlands in 1992, ended by reaching its first market, the US, for the short-term management of severe hypertension, including malignant hypertension, in the hospital setting. Fenoldopam can be prepared in 3 steps from the corresponding phenethylamine and aryloxiran, the pivotal step being the cyclisation in benzazepine in acidic medium. Fenoldopam is a potent dopamine D1 receptor agonist acting peripherally to produce systemic vasodilation.As it does not cross the bloodbrain barrier, it does not exert significant central dopaminergic activity. Fenoldopam also interacts significantly with 5HT1c and 5HT2 receptors. In comparative trials with the most common drug used for this condition in Europe, Fenoldopam was found to be appreciably more potent than nifedipine. Furthermore, Fenoldopam is fast acting and maintains a long-lasting antihypertensive effect.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.

6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Bortribromid 2-Chlor-3,5-dinitrobenzoesaeure 2-Chlor-3,4-dimethoxyphenethylamin

Downstream Produkte

6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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67227-57-0(6-Chlor-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepiniummethansulfonat)Verwandte Suche:

  • 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(4-HYDROXYPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL MESYLATE
  • CORLOPAM MESYLATE
  • FENOLDOPAM MESYLATE
  • 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepinium methanesulphonate
  • Fenodopam mesylate
  • FENOLDOPAM METHANESULFONATE
  • FenoldopamMesylateC16H16C1N03.CH403S
  • (1R)-6-Chloro-2,3,4,5-tetrahydro-1β-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol
  • (R)-SKF-82526
  • SKF R-82526
  • (S)-SKF-82526
  • 8-Chloro-2-(4-hydroxyphenyl)-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol methanesulphonate
  • 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(4-HYDROXYPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL
  • 9CL-CORLOPAM
  • Fenoldopam Mesylate (200 mg)
  • FENOLDIPAM MESYLATE
  • 8-Chloro-2-(4-hydroxyphenyl)-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol methanesulphonate###Unii-inu8H2kawg
  • FENOLDOPAM METHANESULFONATE;CORLOPAM MESYLATE;SKF-82526 MESYLATE
  • SKF-82526 mesylate
  • SKF 82526 (mesylate)， Fenoldopam methanesulfonate， Corlopam mesylate
  • Fenoldopam mesyalte (SKF82526)
  • Fenoldopam Mesylate (1269458)
  • 6-Chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol methanesulfonate
  • 67227-57-0
  • 67227-57-3
  • C16H16ClNO3CH4O3S
  • C17H20ClNO6S
  • CH4O3SC16H16ClNO3
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • BioChemical
  • Biochemicals and Reagents
  • Angiotensin Converting Enzyme
  • A to C
  • CORLOPAM
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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