Sieber Linker
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- CAS-Nr.
- 3722-51-8
- Englisch Name:
- Sieber Linker
- Synonyma:
- HF;3-Hydroxy-9H-xanthen-9-one;Sibur linker;SIEBER LINKER;3-HYDROXYXANTHONE;6-HYDROXY-3-FLUORONE;SALOR-INT L254835-1EA;3-HYDROXY-XANTHEN-9-ONE;SIEBER LINKER, 99% MIN.;3-hydroxy-9H-9-xanthenone
- CBNumber:
- CB3710805
- Summenformel:
- C13H8O3
- Molgewicht:
- 212.2
- MOL-Datei:
- 3722-51-8.mol
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Sieber Linker Eigenschaften
- Schmelzpunkt:
- 243 °C
- Siedepunkt:
- 403.9±24.0 °C(Predicted)
- Dichte
- 1.395±0.06 g/cm3(Predicted)
- storage temp.
- Store at 0°C
- L?slichkeit
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 7.52±0.20(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Orange to Green
- InChI
- InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
- InChIKey
- XCJHDJAODLKGLG-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
- CAS Datenbank
- 3722-51-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| HS Code |
29329900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Sieber Linker Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to off-white or grey powder
Verwenden
Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.
Synthesis Reference(s)
Tetrahedron, 43, p. 3075, 1987
DOI: 10.1016/S0040-4020(01)86849-6
l?uterung methode
Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]
Sieber Linker Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Pyridiniumchlorid
2-Methoxybenzoylchlorid
Salicyls?ure
o-Anissure
Orthophosphorsure
1,3-Dimethoxybenzol
Zinkchlorid
Phosphorylchlorid
1,3-Dihydroxybenzol
Hydrogenchlorid
Diphosphorpentaoxid
Harmol
2,3,4,5,6,7,8,9-Octahydro-1H-trindene
Stilben
3,3'-Dimethyl-benzidin
Downstream Produkte
Sieber Linker Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 219)Lieferanten
3722-51-8()Verwandte Suche:
Glykolsaeure
4-Hydroxybenzoesure
4-Hydroxybenzaldehyd
Methyl-4-hydroxybenzoat
Hydroxy silicone oil
4'-Hydroxyacetophenon
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Hydroxylapatit (Ca5(OH)(PO4)3)
Camptothecin Series--10-hydroxycamptothecin
7H-Furo(3',2',:4,5)furo-(2,3-c)xanthen-7-on, 3a,12c-dihydro-8-hydroxy-6-methoxy-,(3aR-cis)-
Mepixanox
Hydroxyacetonitril
1,7-Dihydroxy-3-methoxyxanthen-9-on
3,6-Bis[2-(dimethylamino)ethoxy]-9H-xanthen-9-ondihydrochlorid
- SIEBER LINKER
- SALOR-INT L254835-1EA
- 6-HYDROXY-3-FLUORONE
- 3-HYDROXY-XANTHEN-9-ONE
- 3-HYDROXYXANTHONE
- SIEBER LINKER,3-HYDROXY-XANTHEN-9-ONE
- 3-HYDROXY-XANTHEN-9-ONE SIEBER LINKER 99+%
- SIEBER LINKER, 99% MIN.
- 3-hydroxy-9H-9-xanthenone
- 3-Hydroxy-9H-xanthen-9-one ,97%
- Sieber linker≥ 99% (HPLC)
- 3-Hydroxyxanthen-9-one>
- 9H-Xanthen-9-one, 3-hydroxy-
- Sieber Linker (3-Hydroxyxanthone) extrapure, 99%
- HF
- 3-Hydroxy-9H-xanthen-9-one
- Sibur linker
- 3722-51-8
- Linkers for Solid Phase Synthesis
- Linkers for solid phase synthesis
- linker
