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PFE-360

PFE-360 Struktur
1527475-61-1
CAS-Nr.
1527475-61-1
Englisch Name:
PFE-360
Synonyma:
PFE-360;PF-06685360;1-Methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile;1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-;1-Methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile , PFE-360;PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2
CBNumber:
CB35419811
Summenformel:
C16H16N6O
Molgewicht:
308.34
MOL-Datei:
1527475-61-1.mol

PFE-360 Eigenschaften

storage temp. 
room temp
L?slichkeit
DMSO: 2 mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

PFE-360 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PFE-360 (PF-06685360) is a poten and elective inhibitor of LRRK2 kinase.

in vitro

PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment potently decreases the LRRK2-pSer935/total LRRK2 ratio, with no significant adverse effects.
animal Model: Female Sprague Dawley rats (NTac:SD) weighed 225-250 g.
Dosage: 4 mg/kg and 7.5 mg/kg (pharmacokinetics and pharmacodynamics).
Administration: Orally BID for 10-12 weeks.
Result: The LRRK2-pSer935/total LRRK2 ratio was significantly decreased at both 1 h and 12 h after dosing.
The terminal bodyweights exhibited no significant changes.

PFE-360 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PFE-360 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 23)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32080 58
NINGBOBENKANGJS PHARMTECHCO., LTD 		+8615990591583 15990591583
 CHINA 2029 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
 3003855609@qq.com China 7887 56
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4512 55
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772
 huahero21@sina.com China 427 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973
 xiaoyangw@gmail.com China 2128 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
 liming@bio-fount.com China 9729 58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. 15990591583
 China 5573 58
  • PFE-360
  • PF-06685360
  • 1H-Pyrrole-2-carbonitrile, 1-methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
  • PF06685360,PF 06685360,LRRK2,inhibit,Inhibitor,PFE 360,PFE360,PFE-360,Leucine-rich repeat kinase 2
  • 1-Methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile , PFE-360
  • 1-Methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile
  • 1527475-61-1
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