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N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid

CIS-THIOTHIXENE Struktur
5591-45-7
CAS-Nr.
5591-45-7
Bezeichnung:
N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid
Englisch Name:
CIS-THIOTHIXENE
Synonyma:
Navan;Navane;Navaron;p-4657-b;Orbinamon;Tiotixene;cp12252-1;CP 12252-1;Thiothixine;Cp-12,252-1
CBNumber:
CB3504781
Summenformel:
C23H29N3O2S2
Molgewicht:
443.63
MOL-Datei:
5591-45-7.mol

N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid Eigenschaften

Dichte
1.1399 (rough estimate)
Brechungsindex
1.6560 (estimate)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 0.5 mg/ml; DMSO: 0.2 mg/ml
Aggregatzustand
A crystalline solid
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.

Verwenden

Thioxanthenes are used as neuroleptic agents, antipsychotics, and major tranquilizers in the treatment of psychosis, including schizophrenia, senile psychosis, pathological jealousy, and borderline personality disorder. Other uses include the treatment of pain, postoperative neuralgia, sedation, anxiety neurosis, childhood behavior problems, and depression. The maximum therapeutic daily oral dose for chlorprothixene, flupenthixol, and thiothixene is 600, 224, and 60 mg, respectively; the maximum intramuscular doses are 200 mg day-1, 100 mg weekly, and 30 mg day-1, respectively. Some thioxanthenes and thioxanthenones have shown signs of possible human therapeutic potential against tumors in mice and in vitro assays, and some thioxanthenes have been shown to have cytotoxic and antimicrobial activities.
Chlorprothixene is primarily indicated in conditions such as agitation, mania, psychosis, schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice for anxiety and herpetic neuralgia. Flupenthixol (HCl and decanoate) is primarily indicated in conditions such as depression, muscle spasms of varied etiology, pain, personality disorder, postoperative nausea and vomiting, psychosis, relief of discomfort in mild urinary tract infections, and schizophrenia. Flupenthixol is also seen to possess powerful antibacterial activity both in vitro and in vivo in mouse experiments. It is bacteriostatic in vitro both against gram-positive and gram-negative bacteria. Thiothixene is used in the management of schizophrenia. It has not been evaluated in the management of behavioral complications in patients with mental retardation.
Zuclopenthixol is primarily indicated in conditions such as dementia, to enhance permeation of subcutaneous or intramuscular injections, labyrinthine disorders, prolactinoma, psychosis, schizophrenia, and second trimester abortion. It is also used in the treatment of acute bipolar mania.

Environmental Fate

Long-range transport: handling of thioxanthenes should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. In case of handling, avoid inhalation and contact with skin, eyes, and clothing, as these materials may be an irritant. These substances are considered nonhazardous for transport.

N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 26)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9447 58
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765
synchempharma@aliyun.com China 6463 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
BOC Sciences --
info@bocsci.com USA 0 65

  • Orbinamon
  • p-4657-b
  • Thiothixine
  • Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-
  • Tiotixene
  • N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
  • N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulphonamide
  • THIOTHIXENE MEETS USP TESTING SPECIFICA
  • THIOTHIXENE,USP
  • TIOTIXENE/THIOTHIXENE
  • (9Z)-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide
  • 2-(Dimethylsulfamoyl)-(9-(4-methyl-1-piperazinyl)propylidene)thioxanthene
  • 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, (Z)-
  • 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-
  • 9h-thioxanthene-2-sulfonamide,n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propyl
  • CP 12252-1
  • Cp-12,252-1
  • CP-12,252-1 base
  • cp12252-1
  • n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thiaxanthene-2-sulfona
  • N,N-Dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thiaxanthene-2-sulfonamide
  • n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfona
  • n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfonami
  • Navan
  • Navane
  • Navaron
  • (Z)-N,N-dimethyl-9-(3-(4-methylpiperazin-1-yl)
  • Thiothixene (Navane)
  • 5591-45-7
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