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  • RO-52 (SSA) HUMAN

    RO-52 (SSA) HUMAN Struktur
    CAS-Nr.
    Englisch Name:
    RO-52 (SSA) HUMAN
    Synonyma:
    RO-52 (SSA) HUMAN
    CBNumber:
    CB3474864
    Summenformel:
    Molgewicht:
    0
    MOL-Datei:
    Mol file

    RO-52 (SSA) HUMAN Eigenschaften

    storage temp. 
    -70°C
    Aggregatzustand
    liquid

    Sicherheit

    Kennzeichnung gef?hrlicher Xi
    R-S?tze: 36/37/38
    S-S?tze: 26-36
    WGK Germany  1

    RO-52 (SSA) HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

    S-S?tze Betriebsanweisung:

    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

    Verwenden

    RO-52 (SSA) human has been used:
    • as a component of the autoantigen array
    • to immobilise protein on the self-assembly monolayer
    • in enzyme-linked immunosorbent assays (ELISAs)

    Allgemeine Beschreibung

    RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.

    Biochem/physiol Actions

    Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

    RO-52 (SSA) HUMAN Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    RO-52 (SSA) HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 2)Lieferanten
    Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
    Riedel-de Haen AG --
    United States 6773 87
    SIGMA-RBI --
    Switzerland 6896 91

    • RO-52 (SSA) HUMAN
    • Auxiliary Proteins
    • Other
    • Proteins and Derivatives
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