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Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat]

Cromolyn Disodium Salt Struktur
15826-37-6
CAS-Nr.
15826-37-6
Bezeichnung:
Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat]
Englisch Name:
Cromolyn Disodium Salt
Synonyma:
SODIUM CROMOGLYCATE;CROMOLYN SODIUM;SODIUM CROMOGLICATE;Cromoglycate;Cromoglycate Sodium;DISODIUM CROMOGLYCATE;DSCG;intal;Allergocrom;SODIUM CHROMOGLICATE
CBNumber:
CB3413920
Summenformel:
C23H17NaO11
Molgewicht:
492.37
MOL-Datei:
15826-37-6.mol

Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat] Eigenschaften

Schmelzpunkt:
241-2420C (dec)
storage temp. 
2-8°C
L?slichkeit
Soluble in water, practically insoluble in ethanol (96 per cent).
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
Soluble in water to 100mg/ml
Merck 
14,2590
Stabilit?t:
Hygroscopyc
InChIKey
VLARUOGDXDTHEH-UHFFFAOYSA-L
CAS Datenbank
15826-37-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
RIDADR  3249
WGK Germany  2
RTECS-Nr. DJ2380000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329990
Toxizit?t LD50 in mice, rats (mg/kg): >8000 orally (Cox)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat] Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White Crystalline Powder

Verwenden

Chromone complex which blocks mast cell degranulation

Definition

ChEBI: An organic sodium salt that is the disodium salt of cromoglycic acid.

Indications

Cromolyn sodium (Intal) is chemically related drugs called chromones that is used for the prophylaxis of mild or moderate asthma. It is administered by inhalation and has very good safety profiles, making them particularly useful in treating children.

Allgemeine Beschreibung

Cromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.
Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.

Mechanism of action

The precise mechanism or mechanisms whereby cromolyn sodium and nedocromil sodium exert their antiasthmatic activities is unknown. Early work suggested that these agents act by “stabilizing” mast cells, preventing mediator release. However, several other compounds exhibit greater potency for stabilization of mast cells yet possess no clinical efficacy in asthma.This suggests that the therapeutic activity of cromolyn sodium and nedocromil sodium in asthma is related to one or more other pharmacological mechanisms. Postulates include inhibitory effects on irritant receptors, nerves, plasma exudation, and inflammatory cells in general.

Pharmakokinetik

Cromolyn sodium is a bischromone that contains the fundamental benzopyrone moiety of khellin. The two chromone rings are necessary for activity and must be coplanar, with a linking chain of no longer than six carbons. If one changes the linking chain to positions 8 and 8′, coplanarity cannot be maintained, and the compound loses all activity. Cromolyn sodium is poorly absorbed from the lungs (~8%), insignificantly from the eye (~0.07%), and by approximately 1% from the GI tract. What little that finds its way into systemic circulation is eliminated intact in the urine and the bile. For the treatment of asthma, cromolyn sodium is available as a solution for both intranasal and inhalation administration. There also is an oral concentrate (100 mg/5 mL), which is administered as a 200-mg dose given four times a day.

Clinical Use

Cromolyn sodium is used almost exclusively for the prophylactic treatment of mild to moderate asthma and should not be used for the control of acute bronchospasm. This agent is effective in about 60 to 70% of children and adolescents with asthma. Unfortunately, there is no reliable means to predict which patients will respond.It is less effective in older patients and in patients with severe asthma. It may take up to 4 to 6 weeks of treatment for cromolyn sodium to be effective in chronic asthma, but it is effective after a single dose in exercise-induced asthma. With respect to clinical efficacy, cromolyn sodium and nedocromil sodium do not differ in a substantial way.

Nebenwirkungen

Cromolyn sodium is the least toxic of available therapies for asthma. Adverse reactions are rare and generally minor. Those occurring in fewer than 1 in 10,000 patients include transient bronchospasm, cough or wheezing, dryness of throat, laryngeal edema, swollen parotid gland, angioedema, joint swelling and pain, dizziness, dysuria, nausea, headache, nasal congestion, rash, and urticaria.

Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat] Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat] Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 420)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12829 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958
bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830
figo.gao@foxmail.com China 8497 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

15826-37-6(Dinatrium-5,5'-[(2-hydroxytrimethylen)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylat])Verwandte Suche:


  • disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4h-1-benzopyran-2-carboxylate]
  • disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol
  • CROMOGLYCATE SODIUM SALT
  • CROMOGLYCIC ACID SODIUM SALT
  • CROMOLYN SODIUM SALT
  • 4h-1-benzopyran-2-carboxylicacid,5,5’-((2-hydroxytrimethylene)dioxy)bis(4-oxo
  • 4H-1-Benzopyran-2-carboxylicacid,5,5’-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-,disodiumsalt
  • 4H-1-Benzopyran-2-carboxylicacid,5,5’-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-,disodiumsalt
  • 5,5’-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylicaci
  • 5,5’-[2-Hydroxy-1,3-propanediyl)bis-(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylicacid]disodiumsalt
  • aarane
  • aararre
  • cromoglycatedisodium
  • Cromoglycicacidsodium
  • d)disodiumsalt
  • dinatriumsalzvon1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan
  • disodium5,5’-((2-hydroxytrimethylene)dioxy)-bis(4-oxo-4h-1-benzopyran-2-carb
  • disodium5,5’-[(2-hydroxytrimethylene)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylate]
  • disodiumchromoglycate
  • disodiumcromoglicate
  • fpl670
  • frenasma
  • inostral
  • lomudal
  • lomudas
  • nalcrom
  • nasmil
  • natriumcromoglicat
  • oxylate)
  • rynacrom
  • sodiumcromolyn
  • 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylic acid) disodium salt
  • CROMOLYN SODIUM (DISODIUM CROMOGLYCATE)
  • Disodium 5,5-[(2-hydroxytrimethylene)-bis-(oxy)]-bis[4-oxo--1-benzopyran-2
  • 1,3-Di-(2-carboxy-4-oxochromen-5-yloxy) propan-2-ol-disodium salt
  • Cromoglycic acid, disodium salt
  • Alloptrex
  • Cromolyn Disodium Salt
  • Nalcro
  • CROMOLYNSODIUM,USP
  • SODIUM CHROMOGLYCATE
  • Sodium Cromoglycate 5,5’-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic Acid] Disodium Salt
  • Dissodium cromoglicate
  • Cromoglicate Sodium
  • Cromolyn sodium salt,Cromoglycate, Cromoglycic acid
  • Cromolyn Sodium (500 mg)
  • CroMolyn DisodiuM Salt Hydrate
  • Disodium Cromoglycate 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylic Acid) Disodium Salt
  • CroMolyn-d5 DisodiuM Salt/ SodiuM CroMoglycate-d5
  • Cromoglycate, Cromoglycic acid
  • 4H-1-Benzopyran-2-carboxylicacid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, sodiuM salt (1:2)
  • 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid,sodium salt (1:2)
  • FPL 670 (Cromolyn) Disodium
  • Sodium cromoglicate for system suitability
  • sodium 5-[3-[(2-carboxy-4-oxo-1-benzopyran-5-yl)oxy]-2-hydroxypropoxy]-4-oxo-1-benzopyran-2-carboxylic acid
  • Cromoiyn Sodium
  • Sodium cromoglicate for system suitability CRS
  • Cromolyn Disodium Salt Hydrate>
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