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(R)-(-)-IBUPROFEN

(R)-(-)-IBUPROFEN Struktur
51146-57-7
CAS-Nr.
51146-57-7
Englisch Name:
(R)-(-)-IBUPROFEN
Synonyma:
(R)-IBUPROFEN;(R)-2-(4-Isobutylphenyl)propanoic acid;l-Ibuprofen;levibuprofen;(-)-Ibuprofen;(-)-Ibuprophen;2-Yl)carbamate;(R)-(-)-Ibupr en;(R)-(-)-IBUPROFEN;Ibuprofen (R)-Isomer
CBNumber:
CB3393273
Summenformel:
C13H18O2
Molgewicht:
206.29
MOL-Datei:
51146-57-7.mol

(R)-(-)-IBUPROFEN Eigenschaften

Schmelzpunkt:
41-42°C
Siedepunkt:
305.14°C (rough estimate)
Dichte
1.0176 (rough estimate)
Brechungsindex
1.5290 (estimate)
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand
White crystalline powder.
pka
4.41±0.10(Predicted)
Farbe
Colourless to Pale Beige Oil
Wasserl?slichkeit
369.3mg/L(25 ºC)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 24/25
HS Code  29155090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(R)-(-)-IBUPROFEN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.

Chemische Eigenschaften

White Crystalline Solid

l?uterung methode

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

(R)-(-)-IBUPROFEN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(R)-(-)-IBUPROFEN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 152)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21638 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29885 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Standardpharm Co. Ltd. 		86-714-3992388
overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32063 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851
 sales@win-winchemical.com China 14349 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 23225 58

51146-57-7()Verwandte Suche:

  • (R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID
  • (R)-(-)-IBUPROFEN
  • (-)-Ibuprophen
  • Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)-
  • Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)-
  • l-Ibuprofen
  • R-(-)-p-Isobutylhydratropic acid
  • (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid
  • Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)-
  • (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
  • levibuprofen
  • Ibuprofen Impurity 20((R)-Isomer)
  • (R)-(-)-Ibupr en
  • (R)-(-)-Ibuprofen ((R)-Ibuprofen)
  • (R)-(-)-ibuprofen reference substance
  • Ibuprofen (R)-Isomer
  • (R)-(-)-IBUPROFEN USP/EP/BP
  • (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What are the applications of (R)-Ibuprofen
  • 5-Triiodo-L-thyronine sodium
  • (R)-IBUPROFEN
  • (R)-2-(4-Isobutylphenyl)propanoic acid
  • (-)-Ibuprofen
  • 2-Yl)carbamate
  • (αR)?-α-?Methyl-?4-?(2-?methylpropyl)?-benzeneacetic Acid
  • 51146-57-7
  • 1146-57-7
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
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