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GIP (HUMAN)

GIP (HUMAN) Struktur
100040-31-1
CAS-Nr.
100040-31-1
Englisch Name:
GIP (HUMAN)
Synonyma:
GIP;GIP (HUMAN);GIP (Total);GIP (active);M.W. 4983.59 C226H338N60O66S;GASTRIC INHIBITORY PEPTIDE HUMAN;GASTRIC INHIBITORY POLYPEPTIDE (HUMAN);YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ;Gastric inhibitorypolypeptide (human) (9CI);Gastric inhibitory polypeptide human, ≥95% (HPLC)
CBNumber:
CB3381115
Summenformel:
C226H338N60O66S
Molgewicht:
4983.52932
MOL-Datei:
100040-31-1.mol

GIP (HUMAN) Eigenschaften

storage temp. 
−20°C
Aggregatzustand
Solid
Farbe
White to off-white
Wasserl?slichkeit
Soluble to 1 mg/ml in water
Sequenz
H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH

Sicherheit

WGK Germany  3

GIP (HUMAN) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GIP was originally isolated as a gastric inhibitory polypeptide. After the discovery of its glucose-dependent insulinotropic activity, known as the incretin effect, GIP was renamed glucose-dependent insulinotropic peptide.
Gastric inhibitory peptide
Abbreviation: GIP
Additional names: gastric inhibitory polypeptide,gastrointestinal inhibitory peptide, glucose-dependent, insulinotropic peptide

Chemische Eigenschaften

Human GIP: Mr 4983.6, theoretical pI 6.92. GIP is soluble in water, but insoluble in ethanol. GIP is inactivated by DPP-4.

History

GIP was originally isolated from the porcine intestinal extract on the basis of its acid inhibitory activity in dogs (gastric inhibitory polypeptide) in the early 1970s, and subsequently renamed glucose-dependent insulinotropic peptide after the finding of its physiologically important role as a potentiator of glucose-stimulated insulin secretion.

Verwenden

GIP possessing incretin activity enhances glucosestimulated insulin release. GIP agonists are potentially useful for the treatment of diabetes. Moreover, DPP-4 inhibitors are approved for use in diabetes patients because GIP is rapidly deactivated by DPP-4.

Biosynthese

The expression of GIP is regulated by nutrients. The administration of glucose and lipid into the rat gastrointestinal tract increases GIP mRNA levels. Circulating GIP levels are low in the fasted state and increase within minutes of food ingestion. The postprandial levels of circulating GIP are dependent on meal size. The degree to which nutrients regulate GIP secretion is speciesdependent. Fat is a more potent stimulator than carbohydrates in humans, whereas in the rodent and pig, carbohydrates are more potent than fat. Once released, GIP is rapidly deactivated by DPP-4.

GIP (HUMAN) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


GIP (HUMAN) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 113)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097
market02@senwayer.com China 902 58
Alpha Biopharmaceuticals Co., Ltd
+86-15542445688
sales@alabiochem.com China 888 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10310 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2524 58
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 1000 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Hangzhou Go Top Peptide Biotech
0571-88211921
sales1@gotopbio.com CHINA 2609 58
Alfa Chemistry

Info@alfa-chemistry.com United States 24072 58

100040-31-1()Verwandte Suche:


  • H-TYR-ALA-GLU-GLY-THR-PHE-ILE-SER-ASP-TYR-SER-ILE-ALA-MET-ASP-LYS-ILE-HIS-GLN-GLN-ASP-PHE-VAL-ASN-TRP-LEU-LEU-ALA-GLN-LYS-GLY-LYS-LYS-ASN-ASP-TRP-LYS-HIS-ASN-ILE-THR-GLN-OH
  • GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (HUMAN)
  • GASTRIC INHIBITORY PEPTIDE HUMAN
  • GASTRIC INHIBITORY POLYPEPTIDE (HUMAN)
  • GIP (HUMAN)
  • GIP
  • YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
  • TYR-ALA-GLU-GLY-THR-PHE-ILE-SER-ASP-TYR-SER-ILE-ALA-MET-ASP-LYS-ILE-HIS-GLN-GLN-ASP-PHE-VAL-ASN-TRP-LEU-LEU-ALA-GLN-LYS-GLY-LYS-LYS-ASN-ASP-TRP-LYS-HIS-ASN-ILE-THR-GLN
  • Gastric Inhibitory Polypeptide (huMan) GIP (huMan), Glucose-Dependent Insulinotropic Polypeptide (huMan)
  • GIP (huMan), Glucose-Dependent Insulinotropic Polypeptide (huMan)
  • GIP, Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln
  • M.W. 4983.59 C226H338N60O66S
  • REF DUPL: H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH
  • Gastric inhibitorypolypeptide (human) (9CI)
  • Gastric Inhibitory Polypeptide huManGastric Inhibitory Polypepti
  • Gastric inhibitory polypeptide human, ≥95% (HPLC)
  • GIP (active)
  • GIP (Total)
  • 100040-31-1
  • C226H338N60O66S
  • Gastrointestinal Products
  • Gastric Inhibitory Polypeptides
  • Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • peptide
  • Glucagon receptor and related
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