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(1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on

Caulophylline Struktur
486-86-2
CAS-Nr.
486-86-2
Bezeichnung:
(1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on
Englisch Name:
Caulophylline
Synonyma:
(1r)-l;Caulophyllin;Caulophylline;Methylcytisine;N-METHYLCYTISINE;12-Methylcytisine;12-methyl-cytisin;N-Methylcytisine-RM;Cytisine, 12-methyl-;METHYLCYTISINE, N-(P)
CBNumber:
CB3366194
Summenformel:
C12H16N2O
Molgewicht:
204.27
MOL-Datei:
486-86-2.mol

(1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on Eigenschaften

Schmelzpunkt:
137-139oC
alpha 
30D -224° (c = 1.05 in water)
Siedepunkt:
342.77°C (rough estimate)
Dichte
1.0565 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
L?slichkeit
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand
powder
pka
9.61±0.20(Predicted)
Farbe
White to Off-White
NIST chemische Informationen
Caulophylline(486-86-2)

Sicherheit

Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  3
RTECS-Nr. HA4400000
Toxizit?t LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)

(1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]20D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.

Chemische Eigenschaften

Colourless Needles

Verwenden

N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

Allgemeine Beschreibung

N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.

Hazard

Extremely toxic; cardiotoxic; poisonous.

Einzelnachweise

Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)

(1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 201)Lieferanten
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ATK CHEMICAL COMPANY LIMITED
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Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
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Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58

486-86-2((1R)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-on)Verwandte Suche:


  • N-METHYLCYTISINE
  • (1r)-l
  • 1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy
  • 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)-
  • 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)-
  • 12-methyl-cytisin
  • 12-Methylcytisine
  • Caulophyllin
  • Caulophylline
  • Cytisine, 12-methyl-
  • (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
  • (1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
  • (1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one
  • [1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one
  • METHYLCYTISINE, N-(P)
  • N-Methylcytisine AldrichCPR
  • Methylcytisine
  • N-Methylcytisine hydrobromide
  • N-Methylcytisine, 98%, from Sophora flavescens Aiton
  • 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)-
  • Caulophylline USP/EP/BP
  • (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]...
  • (1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one
  • Caulophylline (N-Methylcytisine)
  • N-Methylcytisine-RM
  • 486-86-2
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • Miscellaneous Reagents
  • standardized herbal extract
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