ANTALARMIN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

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Beschreibung

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (K_i = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress. Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli. It has also been shown to reduce dose escalation in cocaine-addicted rats, to produce anti-inflammatory effects in arthritis models, and to suppress stress-induced gastric ulceration related to irritable bowel syndrome.

Verwenden

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biologische Aktivit?t

Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

ANTALARMIN HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ANTALARMIN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Nantong Hi-Future Biotechnology Co., Ltd	18051384581	sales@chemhifuture.com	China	3021	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
ATK CHEMICAL COMPANY LIMITED	021-51619050 13301662590	mandy@atkchemical.com	China	7821	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9805	58

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• ANTALARMIN HYDROCHLORIDE
• N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE
• N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
• N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride
• Antalarmin hydrochlo
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)
• N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
• 220953-69-5
• C24H34N4HCl