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H-8 DIHYDROCHLORIDE

H-8 DIHYDROCHLORIDE Struktur
113276-94-1
CAS-Nr.
113276-94-1
Englisch Name:
H-8 DIHYDROCHLORIDE
Synonyma:
H-8;H-8 HYDROCHLORIDE;H-8 DIHYDROCHLORIDE;H-8 dihydrochloride,98%;H8, dihydrochloride salt;H-8 dihydrochloride >98% (HPLC);H8 (hydrochloride),H 8 (hydrochloride);H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C;N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide;2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium
CBNumber:
CB3341825
Summenformel:
C12H17Cl2N3O2S
Molgewicht:
338.25
MOL-Datei:
113276-94-1.mol

H-8 DIHYDROCHLORIDE Eigenschaften

Schmelzpunkt:
221-222℃ (methanol water )
storage temp. 
2-8°C
L?slichkeit
ethanol: 25 mg/mL, clear, colorless
Aggregatzustand
Lyophilized
Farbe
White to Off-White
CAS Datenbank
113276-94-1(CAS DataBase Reference)

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
HS Code  29334990

H-8 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively.

Chemische Eigenschaften

white to off-white crystalline solid

Verwenden

Active inhibitor of cyclic-nucleotide-dependent protein kinases.

H-8 DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

H-8 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 75)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30239 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32343 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 021-61259108 18621169109
 market03@meryer.com China 40228 62
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50

113276-94-1()Verwandte Suche:

  • 5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2)
  • H-8 DIHYDROCHLORIDE
  • H-8 HYDROCHLORIDE
  • H-8
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE
  • N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
  • N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-5-SULFONAMIDE DIHYDROCHLORIDE
  • H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C
  • H-8 dihydrochloride,98%
  • N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
  • H8, dihydrochloride salt
  • 2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium
  • H-8 dihydrochloride >98% (HPLC)
  • H8 (hydrochloride),H 8 (hydrochloride)
  • 113276-94-1
  • C12H15N3O2S2HCl
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