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17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Struktur
221246-34-0
CAS-Nr.
221246-34-0
Englisch Name:
17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA
Synonyma:
CMLNDCUXASGBMQ-NQUQXYBYSA-N;17-trifluoromethylphenyl trinor Prostaglandin F2α;17-trifluoromethylphenyl trinor Prostaglandin F2α;17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA;9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pent-1-en-1-yl)cyclopentyl)hept-5-enoic acid;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, (5Z)-
CBNumber:
CB3320675
Summenformel:
C24H31F3O5
Molgewicht:
456.5
MOL-Datei:
221246-34-0.mol

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Eigenschaften

Siedepunkt:
593.0±50.0 °C(Predicted)
Dichte
1.296±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
pka
4.76±0.10(Predicted)

Sicherheit

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946
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 jinoupharma@163.com China 11721 58
TargetMol Chemicals Inc. 4008200310
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  • 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • 17-trifluoromethylphenyl trinor Prostaglandin F2α
  • 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA
  • CMLNDCUXASGBMQ-NQUQXYBYSA-N
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, (5Z)-
  • 17-trifluoromethylphenyl trinor Prostaglandin F2α
  • (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pent-1-en-1-yl)cyclopentyl)hept-5-enoic acid
  • 221246-34-0
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