PCNA-I1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (K_d = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC₅₀s = 0.05-0.3 μM) over non-transformed cells (IC₅₀s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G₁ phase during the first 24 hours of incubation and halts the cell cycle in the S and G₂/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.

PCNA-I1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PCNA-I1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32080	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38470	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2317	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	4418	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8011	62

---

• N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
• 2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
• PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1
• N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide
• N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide
• 444930-42-1