SR 59230A HCl Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

SR 59230A (hydrochloride) is a β₃-adrenergic receptor (β₃-AR) antagonist (pA₂s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for β₃-AR in cells transfected with the human β-AR subtypes (K_is = 16.4, 61.9, and 122 nM for β₁-, β₂-, and β₃-AR, respectively). At low concentrations, SR 59230A blocks MDMA-induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss through an α₁-AR antagonistic mechanism. In adipocytes, it induces phosphorylation of p38 MAPK via the G_s pathway. It has also been used in studies of heart failure to elucidate the role of the β₃-ARs.

Verwenden

SR 59230A Hydrochloride is a potent and selective β3 adrenergic receptor antagonist.

SR 59230A HCl Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SR 59230A HCl Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	5926	55
BOC Sciences	--	info@bocsci.com	USA	0	65
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58

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• 1135278-41-9