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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Struktur
68341-09-3
CAS-Nr.
68341-09-3
Englisch Name:
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
Synonyma:
CUAM;Cu-ASTM;Cu-ATSM;CuII(atsm);Cu-ASTM >=98% (HPLC);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
CBNumber:
CB32750504
Summenformel:
C8H14CuN6S2
Molgewicht:
321.91296
MOL-Datei:
68341-09-3.mol

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Eigenschaften

storage temp. 
2-8°C
L?slichkeit
DMSO: soluble10mg/mL, clear
Aggregatzustand
powder
Farbe
brown to dark red-brown

Sicherheit

WGK Germany  3

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 25)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
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Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
YangZhou Ruihong Biotech Co., Ltd. 015380367604 15380367604
China 510 55
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
klq@cw-bio.com China 4966 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58

  • [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
  • Cu-ASTM
  • CuII(atsm)
  • Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)
  • CUAM
  • Cu-ATSM
  • Cu-ASTM >=98% (HPLC)
  • 68341-09-3
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