(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
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- CAS-Nr.
- 1197953-49-3
- Englisch Name:
- (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- Synonyma:
- (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;AP26113 intermediates 1;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine;2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...;4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-;2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide;2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
- CBNumber:
- CB32677388
- Summenformel:
- C12H12Cl2N3OP
- Molgewicht:
- 316.12
- MOL-Datei:
- 1197953-49-3.mol
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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Eigenschaften
- Siedepunkt:
- 527.5±50.0 °C(Predicted)
- Dichte
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.30±0.10(Predicted)
- InChI
- InChI=1S/C12H12Cl2N3OP/c1-19(2,18)10-6-4-3-5-9(10)16-11-8(13)7-15-12(14)17-11/h3-7H,1-2H3,(H,15,16,17)
- InChIKey
- XIKUAKVCJMVXCI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is a pharmaceutical intermediate compound used in the synthesis of the antitumour agent Brigatinib. Brigatinib is an orally administered, potent, selective anaplastic lymphoma kinase ( Brigatinib is an oral, potent, selective anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) tyrosine kinase inhibitor approved for the treatment of adult patients with advanced ALK-positive non-small cell lung cancer (NSCLC) who have not received prior ALK inhibitor therapy.
Verwenden
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is an intermediate of AP26113 which is a kind of effective ALK inhibitor.
Synthese
25 mL of a one-necked flask was added DMF (3 mL), 2,5,6-trichloro pyrimidine (0.72 g, 3.9 mmol) was added successively with stirring,2- (dimethylphosphonino) aniline (0.5 g, 3 mmol)Anhydrous potassium carbonate (0.62 g, 4.5 mmol), heated to 60 ° C and stirred for 4 h.(30 mL x 2), the organic phase was combined, washed with water (60 mL x 2), and the organic layer was dried over anhydrous sodium sulfate, and the organic layer was washed with ethyl acetate (30 mL) and water (30 mL) Filtered and concentrated, and the residue was passed through a silica gel column to give 0.8 g of a pale yellow solid (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 163)Lieferanten
- 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine
- 4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine
- 2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide
- 2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine
- 4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-
- 2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...
- (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
- 2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *
- AP26113 intermediates 1
- 1197953-49-3
- 197953-49-3
- 761140-75-9
- C12H12Cl2N3OP
- 1197953-49-3
