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9-Nitrominocycline

9-Nitrominocycline Struktur
149934-16-7
CAS-Nr.
149934-16-7
Englisch Name:
9-Nitrominocycline
Synonyma:
9-Nitro Minocycline;Tigecycline Impurity G;Tigecycline Impurity 12;GEGDTZYTPKKFGB-IRDJJEOVSA-N;TigecyclineImpurity12Hemisulfate;(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino);Minocycline Impurity 5(Minocycline 9-Nitro Impurity);Minocycline EP Impurity G Intermediate(9-Nitro Minocycline);Minocycline Impurity 5 Hemisulfate(Minocycline 9-Nitro Impurity Hemisulfate);Minocycline 9-Nitro ImpurityQ: What is Minocycline 9-Nitro Impurity Q: What is the CAS Number of Minocycline 9-Nitro Impurity
CBNumber:
CB32622575
Summenformel:
C23H26N4O9
Molgewicht:
502.47
MOL-Datei:
149934-16-7.mol

9-Nitrominocycline Eigenschaften

Siedepunkt:
825.9±65.0 °C(Predicted)
Dichte
1?+-.0.1 g/cm3(Predicted)
pka
4.50±1.00(Predicted)

Sicherheit

9-Nitrominocycline Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

9-Nitrominocycline is a 9-substituted Minocycline (M344800) derivative used as antibacterial agent.

Indications

Minoxidil, an antihypertensive agent, produces arteriolar vasodilation by an unknown mechanism. In limited clinical studies, minoxidil increases penile rigidity and has been used in the long-term treatment of organic impotence.

Biologische Funktion

Minoxidil (Loniten) is an orally effective vasodilator. It is more potent and longer acting than hydralazine and does not accumulate significantly in patients with renal insufficiency. It depends on in vivo metabolism by hepatic enzymes to produce an active metabolite, minoxidil sulfate. Minoxidil sulfate activates potassium channels, resulting in hyperpolarization of vascular smooth muscle and relaxation of the blood vessel.

Pharmakologie

The hemodynamic effects of minoxidil are generally similar to those of hydralazine, with the noteworthy exception that a greater decrease in peripheral vascular resistance and consequently a larger reduction in blood pressure can be achieved with minoxidil. Minoxidil produces no important changes in either renal blood flow or glomerular filtration rate. It has little or no effect on venous capacitance and does not inhibit the reflex activation of the sympathetic nervous system. Orthostasis and other side effects of sympathetic blockade are therefore not a problem. As with hydralazine, there is a significant increase in cardiac output that is secondary to reflex increases in sympathetic activity, hyperreninemia, and salt and water retention.These effects can substantially reduce the effectiveness of minoxidil when it is used alone.The addition of a -blocker and a diuretic to the therapeutic regimen will preserve minoxidil’s antihypertensive action while attenuating some of the undesirable side effects.

Clinical Use

The major indications for the use of minoxidil are (1) severe hypertension that may be life threatening and (2) hypertension that is resistant to milder forms of therapy. Compromises in renal function do not prolong either the plasma or the therapeutic half-life of minoxidil, and therefore, it seems to be particularly important for hypertensive patients with chronic renal failure.

Nebenwirkungen

Signs of toxicity common to vasodilator therapy in general also occur with minoxidil; they are attributable to vasodilation and reflex increases in sympathetic nerve activity. These include headache, nasal congestion, tachycardia, and palpitations. These effects do not have great clinical importance, since minoxidil is almost always administered in combination with a -blocker, which antagonizes the indirect cardiac effects. A more troublesome side effect, particularly in women, is the growth of body hair, possibly due to a direct stimulation of the growth and maturation of cells that form hair shafts. Apparently, minoxidil activates a specific gene that regulates hair shaft protein. In any case, this particular side effect has been capitalized upon, and minoxidil is now marketed as Rogaine for the treatment of male pattern baldness.

Stoffwechsel

Peak concentrations of minoxidil in the blood occur 1 hour after oral administration, although the therapeutic effect may take 2 or more hours to manifest. This is probably related to the time it takes to convert minoxidil to minoxidil sulfate. The antihypertensive action after an oral dose of minoxidil lasts 12 to 24 hours. The long duration of action allows the drug to be administered only once or twice a day, a regimen that may be beneficial for compliance. Interestingly, the therapeutic half-life is considerably longer than the plasma half-life. This may be, as has been suggested for hydralazine, a result either of accumulation of the drug and its active metabolite in arterial walls or a longer plasma half-life of the sulfated metabolite, or both.
The ultimate disposition of minoxidil depends primarily on hepatic metabolism and only slightly on renal excretion of unchanged drug. Because of this, pharmacological activity is not cumulative in patients with renal failure.

9-Nitrominocycline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9-Nitrominocycline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 24)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11922 58
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9460 58
Guangzhou PI PI Biotech Inc 020-81716320 +86-13602409664
Sales@pipitech.com China 3633 55
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15402 60
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18070 56
Hubei Yangxin Medical Technology Co., Ltd. 15374522761
3003392093@qq.com China 8705 55
Alchemist-pharm chemical Technology Co. Ltd. 0371-67991738 13783628208
carl@alchemist-pharm.com China 1872 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
sales@rrkchem.com China 57423 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 020-36607679 17825480238
3008233746@qq.com China 9919 12

149934-16-7()Verwandte Suche:


  • (4S,4aS,5aR,12aS)-4,7-Bis(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-2-naphthacenecarboxaMide
  • [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-2-naphthacenecarboxaMide
  • 9-Nitro Minocycline
  • Tigecycline Impurity G
  • (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)
  • Tigecycline Impurity 12
  • GEGDTZYTPKKFGB-IRDJJEOVSA-N
  • Minocycline Impurity 5(Minocycline 9-Nitro Impurity)
  • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-, (4S,4aS,5aR,12aS)-
  • Minocycline EP Impurity G Intermediate(9-Nitro Minocycline)
  • Minocycline 9-Nitro ImpurityQ: What is Minocycline 9-Nitro Impurity Q: What is the CAS Number of Minocycline 9-Nitro Impurity
  • (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • TigecyclineImpurity12Hemisulfate
  • Minocycline Impurity 5 Hemisulfate(Minocycline 9-Nitro Impurity Hemisulfate)
  • 149934-16-7
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  • Aromatics
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