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Toceranib

Toceranib Struktur
356068-94-5
CAS-Nr.
356068-94-5
Englisch Name:
Toceranib
Synonyma:
CS-1158;SU-11654;Toceranib;PHA 291639;Toceranib-d8;Toceranib(SU 11654;Toceranib free base;Toceranib,PHA-291639;Toceranib DISCONTINUED;TOCERANIB;SU 11654;PHA 291639
CBNumber:
CB32518368
Summenformel:
C22H25FN4O2
Molgewicht:
396.46
MOL-Datei:
356068-94-5.mol

Toceranib Eigenschaften

Schmelzpunkt:
>133°C (dec.)
Siedepunkt:
596.8±50.0 °C(Predicted)
Dichte
1.293
storage temp. 
room temp
L?slichkeit
DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
Aggregatzustand
powder
pka
11.70±0.20(Predicted)
Farbe
yellow to orange
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Toceranib Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

Toceranib (SU11654) is a protein tyrosine kinase inhibitor that selectively targets stem cell factor receptor c-kit, including all forms of mutant Kit, as well as PDGFR and VEGFR. Toceranib exhibited Ki values of 5 nM for PDGFR and 6 nM for VEGFR. Toceranib phosphate is approved for use in mast cell cancer in dogs.

Toceranib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Pyrrole-3-carboxamide, 5-formyl-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]- Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 5-Fluoro-2-oxindole 5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 3,5-Dimethylpyrrole-2,4-dicarboxylic acid 2-t-butyl ester-4-ethyl ester N-(2-Aminoethyl)pyrrolidin

Downstream Produkte

Toceranib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 118)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3009 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 31991 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551
sales@afinechem.com China 15361 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38460 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490
 info@gihichemicals.com China 49979 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
  • (Z)-5-(5-Fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidenemethyl)-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
  • SU-11654
  • Toceranib
  • (Z)-5-[(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
  • 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylideneMethyl)-2,4-diMethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl)ethyl)aMide
  • 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxaMide
  • PHA 291639
  • 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylideneMethyl)-2,4-diMethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl-d8)ethyl)aMide
  • 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl-d8)ethyl]-1H-pyrrole-3-carboxaMide
  • Toceranib-d8
  • Toceranib (PHA 291639, SU 11654)
  • Toceranib,PHA-291639
  • 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrol-3-carboxamide
  • Toceranib(SU 11654
  • TOCERANIB;SU 11654;PHA 291639
  • (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-p
  • 5-HYDROXY-2-(4-HYDROXY-3-METHOXYPHENYL)-7-METHOXY-4H-CHROMEN-4-ONE
  • 1H-Pyrrole-3-carboxaMide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]-
  • CS-1158
  • SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639
  • Toceranib free base
  • Toceranib DISCONTINUED
  • (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide
  • 5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide
  • 356068-94-5
  • 256068-94-5
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