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STAT5 Inhibitor

STAT5 Inhibitor Struktur
285986-31-4
CAS-Nr.
285986-31-4
Englisch Name:
STAT5 Inhibitor
Synonyma:
MDK6314;CS-2509;STAT5-IN-1;STAT5 Inhibitor;STAT5 Inhibitor 1;Stat5 Inhibitor(STAT5-IN-1);N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT;N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
CBNumber:
CB32515923
Summenformel:
C16H11N3O3
Molgewicht:
293.28
MOL-Datei:
285986-31-4.mol

STAT5 Inhibitor Eigenschaften

Schmelzpunkt:
214-216 °C
Dichte
1.33±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
L?slichkeit
≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Aggregatzustand
crystalline solid
pka
10.44±0.46(Predicted)
Farbe
White to light yellow

Sicherheit

STAT5 Inhibitor Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 μM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 μM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.

Verwenden

2-?[(4-?Oxo-?4H-?1-?benzopyran-?3-?yl)?methylene]?hydrazide-3-?pyridinecarboxylic Acid is a selective inhibitor of STAT5.

Definition

ChEBI: A carbohydrazide that is nicotinohydrazide in which the terminal nitrogen has undergone formal condensation with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. It is an inhibitor of STAT5 (Signal Transducer and Activator of Tran cription 5) protein.

STAT5 Inhibitor Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

STAT5 Inhibitor Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 80)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30236 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
  • STAT5-IN-1
  • N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
  • STAT5 Inhibitor
  • CS-2509
  • STAT5 Inhibitor 1
  • (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
  • MDK6314
  • 3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide
  • STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT
  • Stat5 Inhibitor(STAT5-IN-1)
  • N'3-[(4-oxo-4H-chromen-3-yl)methylidene]pyridine-3-carbohydrazide
  • N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
  • 3-{[(1E)-2-(pyridin-3-ylcarbonyl)diazanylidene]methyl}-4H-chromen-4-one
  • 285986-31-4
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