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CINOXACIN

CINOXACIN Struktur
28657-80-9
CAS-Nr.
28657-80-9
Englisch Name:
CINOXACIN
Synonyma:
cinobac;Cinoxacin Solution in Methanol/DMSO, 1000μg/mL;1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid;CINOXACIN;Cinoxacino;Cinoxacinum;Compound 64716;Cinoxacin (200 mg);Cinoxacin (Cinobac;TIMTEC-BB SBB003082
CBNumber:
CB3200706
Summenformel:
C12H10N2O5
Molgewicht:
262.22
MOL-Datei:
28657-80-9.mol

CINOXACIN Eigenschaften

Schmelzpunkt:
261-262° (dec)
Siedepunkt:
405.47°C (rough estimate)
Dichte
1.3545 (rough estimate)
Brechungsindex
1.6660 (estimate)
storage temp. 
2-8°C
L?slichkeit
1 M NaOH: soluble50mg/mL
pka
pKa 5.38(H2O t=25.0 I=0.025) (Uncertain)
Aggregatzustand
solid
Farbe
White to Off-White
Stabilit?t:
Hygroscopic
CAS Datenbank
28657-80-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  2
RTECS-Nr. JI4640000
Toxizit?t LD50 in rats (mg/kg): 4160 orally; 900 i.v. (Narama)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

CINOXACIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Cinoxacin is an antibacterial quinolone previously known for its use in the treatment of urinary tract infections.

Definition

ChEBI: A member of the class of cinnolines that is 6,7-methylenedioxycinnolin-4(1H)-one bearing an ethyl group at position 1 and a carboxylic acid group at position 3. An analogue of oxolinic acid, it has similar antibacterial actions. It was formerly used for the treatment of urinary tract infections.

Antimicrobial activity

This drug is effective with respect to Gram-negative microorganisms and is used for the same indications as nalidixic and oxolinic acids. Synonyms of this drug are cinobactin, nossacin, uronorm, and others.

Pharmazeutische Anwendungen

A cinnoline derivative formulated for oral administration. It is active against most Enterobacteriaceae, but Ps. aeruginosa, Gram-positive bacteria and anaerobes are resistant.
It is well-absorbed when given orally. Administration with food reduces the peak concentration by about one-third, but the area under the concentration–time curve (AUC) remains unchanged. Concentrations in prostatic and bladder tissues reach 60% and 80%, respectively, of the simultaneous serum concentrations.
It is almost entirely eliminated in the urine, about 40–60% as unchanged drug and the rest as metabolites, most of which have no antibacterial activity. Urinary concentrations of active drug in the first 2 h after administration of a dose is 100–500 mg/L. Elimination is reduced by probenecid and by renal impairment, the half-life rising to about 12 h in endstage renal failure.
Adverse reactions that are common to the group are reported in 4–5% of patients; these are primarily gastrointestinal tract disturbances, but rashes occur in up to 3% and CNS disturbances in less than 1%. Use is restricted to uncomplicated urinary tract infection.

Clinical Use

1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5g]cinnoline-3-carboxylic acid (Cinobac) is a close congener (isostere) ofoxolinic acid (no longer marketed in the United States) andhas antibacterial properties similar to those of nalidixic andoxolinic acids.
It is recommended for the treatment of urinary tract infectionscaused by strains of Gram-negative bacteria susceptibleto these agents. Early clinical studies indicate that thedrug possesses pharmacokinetic properties superior to thoseof either of its predecessors. Thus, following oral administration,higher urinary concentrations of cinoxacin thanof nalidixic acid or oxolinic acid are achieved. Cinoxacinappears to be more completely absorbed and less proteinbound than nalidixic acid.

CINOXACIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CINOXACIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 115)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19885 58

28657-80-9()Verwandte Suche:


  • Cinoxacino
  • Cinoxacinum
  • CINOXACIN
  • TIMTEC-BB SBB003082
  • 1-ethyl-6,7-methylenedioxy-4(1h)-oxocinnoline-3-carboxylicacid
  • 3)dioxolo(4,5-g)cinnoline-3-carboxylicacid,1,4-dihydro-1-ethyl-4-oxo-(
  • 1-ETHYL-1,4-DIHYDRO-4-OXO[1,3]DIOXOLO[4,5-G]CINNOLINE-3-CARBOXYLIC ACID
  • Cinoxacin (200 mg)
  • Cinoxacin Solution, 1000ppm
  • 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
  • Compound 64716
  • [1,3]Dioxolo[4,5-g]cinnoline-3-carboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-
  • CINOXACIN USP/EP/BP
  • cinobac
  • 1-ethyl-4-oxo-1,4-dihydro-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
  • Cinoxacin Solution in Methanol/DMSO, 1000μg/mL
  • Cinoxacin (Cinobac
  • Cinoxacin in Methanol
  • Cinoxacin in Acetonitrile(DMSO)
  • Terbinafine Impurity 34
  • 28657-80-9
  • BioChemical
  • Antibiotics A to Z
  • Antibiotics A-F
  • Antibiotics
  • CINOBAC
  • Interferes with DNA SynthesisAntibiotics
  • Quinolones and FluoroquinolonesMore...Close...
  • A - KAntibiotics
  • Antibacterial
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Antibiotics by Application
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Inhibits an EnzymeAntibiotics
  • Mechanism of Action
  • Spectrum of Activity
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