p-Toluenesulfonic acid monohydrate
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- CAS-Nr.
- 6192-52-5
- Englisch Name:
- p-Toluenesulfonic acid monohydrate
- Synonyma:
- PTSA;TOLUENE-4-SULFONIC ACID;PTX;PTSA.H2O;4-Methylbenzenesulfonic acid hydrate;TOLUENESULFONIC ACID MONOHYDRATE;PARA TOLUENE SULFONIC ACID;p-Toluenesulfonic acid hydrate;4-TOLUENESULFONIC ACID MONOHYDRATE;PTSA Monohydrate
- CBNumber:
- CB3173385
- Summenformel:
- C7H10O4S
- Molgewicht:
- 190.22
- MOL-Datei:
- 6192-52-5.mol
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p-Toluenesulfonic acid monohydrate Eigenschaften
- Schmelzpunkt:
- 96-99 °C(lit.)
- Siedepunkt:
- 140°C 20mm
- chüttdichte
- 510kg/m3
- Dichte
- 1,24 g/cm3
- Dampfdichte
- 5.9 (vs air)
- Brechungsindex
- 1,382-1,384
- Flammpunkt:
- 180 °C
- storage temp.
- Store at +5°C to +30°C.
- L?slichkeit
- H2O: 0.1 g/mL, clear
- Aggregatzustand
- Solid
- Colour Index
- 42655
- Farbe
- White to pink
- PH
- 1 (650g/l, H2O, 20℃)(anhydrous substance)
- Wasserl?slichkeit
- soluble
- Sensitive
- Hygroscopic
- Merck
- 14,9533
- BRN
- 3568023
- Stabilit?t:
- Stable. Incompatible with strong oxidizing agents, strong bases, most common metals. Protect from moisture.
- InChIKey
- KJIFKLIQANRMOU-UHFFFAOYSA-N
- CAS Datenbank
- 6192-52-5(CAS DataBase Reference)
- EPA chemische Informationen
- Benzenesulfonic acid, 4-methyl-, monohydrate (6192-52-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,C |
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| R-S?tze: |
36/37/38-34-37 |
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| S-S?tze: |
26-37-45-36/37/39 |
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| RIDADR |
UN 2585 8/PG 3 |
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| WGK Germany |
- |
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| RTECS-Nr. |
XT6300000 |
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| F |
3 |
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| Selbstentzündungstemperatur |
600 °C |
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| TSCA |
Yes |
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| HazardClass |
8 |
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| PackingGroup |
III |
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| HS Code |
29041000 |
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| Toxizit?t |
LD50 orally in Rabbit: 2570 mg/kg |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H290 |
Kann gegenüber Metallen korrosiv sein. |
Korrosiv gegenüber Metallen |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P234, P390, P404 |
| H314 |
Verursacht schwere Ver?tzungen der Haut und schwere Augensch?den. |
?tzwirkung auf die Haut |
Kategorie 1B |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| H412 |
Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P234 |
Nur im Originalbeh?lter aufbewahren. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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p-Toluenesulfonic acid monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37:Geeignete Schutzhandschuhe tragen.
Chemische Eigenschaften
White crystals
Verwenden
p-Toluenesulfonic acid monohydrate is used as a catalyst in the synthesis of resveratrol, in oxane derivatives as an antimalarial agent, as substituted piperidine and unsymmetrical benzyl. It acts as a catalyst in the preparation of 1,3,5-trisubstituted pyrazoles derivatives, selenated ketene dithioacetals, triazoloquinazolinone and benzimidazoquinazolinone derivatives. It also serves as an intermediate in the esterification and in reductive amination reactions.
Allgemeine Beschreibung
p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with
P2
1/
c space group. Its solubility in aqueous sulfuric acid solutions has been studied.
l?uterung methode
Purify the acid by precipitation from a saturated solution at 0o by introducing HCl gas. It can also be crystallised from conc HCl, then crystallised from dilute HCl (charcoal) to remove benzenesulfonic acid. It has been crystallised from EtOH/water. Dry it in a vacuum desiccator over solid KOH and CaCl2. p-Toluenesulfonic acid can be dehydrated by azeotropic distillation with *benzene or by heating at 100o for 4hours under water-pump vacuum. The anhydrous acid can be crystallised from *benzene, CHCl3, ethyl acetate, anhydrous MeOH, or from acetone by adding a large excess of *benzene. It can also be dried under vacuum at 50o. The S-benzylisothiuronium salt has m 182o (from aqueous EtOH). [Beilstein 11 IV 241.]
p-Toluenesulfonic acid monohydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE
Pyridiniumtoluol-4-sulfonat
Methylhydroxyacetat
Ethyl (R)-2-hydroxy-4-phenylbutyrate
Saquinavir
LENAMPICILLIN
2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID
Clemizol
Doxifluridin
Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-on
Cefoperazon
4-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,3-THIADIAZOL-5-AMINE
4-PYRIDINEETHANETHIOL HYDROCHLORIDE
4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE
4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE
2-(3-CHLOROPROPYL)-1,3-DIOXOLANE
METHYL 4-BROMO-3-OXOPENTANOATE
Methyl-2,5-dihydro-3-thenoat-1,1-dioxid
2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID
4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE
4-(4-CHLOROPHENYL)-1,2,3-THIADIAZOL-5-AMINE
2-Phenyl-2-imidazolin
p-Toluenesulfonic acid monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 639)Lieferanten
6192-52-5()Verwandte Suche:
- Lisinopril EP IMpurity B
- p-Toluenesulfonic Acid, Monohydrate, ACS
- Benzenesulfonic acid,4-Methyl-, hydrate (1:1)
- P-toluene sulfonic acid(water
- p-Toluenesulfonic acid Monohydrate >=98.0% (T), >=98.0% (HPLC)
- p-Toluenesulfonic acid monohydrate ACS reagent, >=98.5%
- p-Toluenesulfonic acid monohydrate ReagentPlus(R), >=98%
- p-Toluenesulfonic acid monohydrate Vetec(TM) reagent grade, 98%
- Toluenesulfonic acid mixture of isomers monohydrate
- PTS-ACID MONOHYDRATE
- P-TOLUENESULFONIC ACID MONOHYDRATE, 98.5 +%, A.C.S. REAGENT
- P-TOLUENESULFONIC ACID MONOHYDRATE, REAGENTPLUS, 98.5%
- (R)-3-BENZYLOXY-PYRROLIDINE
- P-TolueneSulfonicAcidForSynthesis
- P-TolueneSulfonicAcidGr
- p-Toluenesulfonic acid monohydrate, 98+%
- PARA-TOLUENE SULPHONIC ACID (P.T.S.A.)
- p-Toluenesulfonic acid monohydrate
- p-Toluenesulfonic acid monohydrate, ACS, 98.5% min.
- 4-Toluenesulfonic acid monohydrate≥ 97% (Assay)
- para-Toluenesulfonic acid monohydrateACS reagent,
≥ 98.5% (Titration)
- Toluene-4-sulfonic acid monohydrate for synthesis
- Toluene-4-sulfonic acid monohydrate for analysis EMSURE ACS
- p-Toluenesulfonic acid, Monohydrate, For Synthesis
- p-Toluenesulfonic acid monohydrate, >98.5% (total TSA)
- METHYLBENZENESULFONIC ACID MONOHYDRATE
- p-Toluenesulfonic acid monohydrate, extra pure, 99%
- p-Toluenesulfonic acid monohydrate, pure, 97.5%
- p-TOLUENESULFONIC ACID MONOHYDRATE, REAGENT (ACS)
- Benzenesulfonic acid, 4-methyl-, monohydrate
- P-TOLUENESULFONICACID,MONOHYDRATE,PRACTICAL
- PARA-TOLUENESULPHONICACID,MONOHYDRATE
- p-Toluenesulfonic acid monohydrate, ACS, 98.5+%
- Toluenesulphonic acid monohydrate, para: (4-Methylbenzenesulphonic acid monohydrate)
- Toluenesulfonic Acid, P-
- p-Toluenesulphonic acid monohydrate, 98+%
- p-TOLUENESULPHONIC ACID MONOHYDRATE extrapure AR
- p-Toluenesulfonic Acid, Monohydrate, Reagent
- P-TOLUENESULFONIC ACID MONOHYDRATE
- p-Toluenesulfonicacid,monohyd
- TOS-OH H2O
- P-toluenesulfonic acid free acid*monohydrate
- p-Toluenesulfonicx acid monohydrate
- PTSA~Tosic acid monohydrate~TosOH.H_2O~TsOH.H_2O
- p-Touenesulfonic acid
- PARA-TOLUENESULFONIC ACID MONOHYDRATE, 9 8%
- P-TOLUENESULFONIC ACID MONOHYDRATE REA&
- TOLUENE-4-SULFONIC ACID MONOHYDR., FOR T HE DETERM. OF ACYL
- p-Toluenesulfonic acid monohydrate, 97.5%, pure
- p-Toluenesulfonic acid monohydrate, pure
- p-Toluenesulfonic acid monohydrate,99%,extrapure
- p-Toluenesulfonic acid monohydrate,99%
- Toluene-4-sulfonic acid monohydrate, synthesis grade
- Toluene-4-sulfonic acid monohydrate, reagent grade
- para-TOLUENESULFONIC ACID MONOHYDRATE, REAGENT (ACS)
- p-Toluenesulfonic acid Monohy
- p-Toluenesulfonic acid Monohydrate, extra pure, 99% 100GR
- p-Toluenesulfonic acid Monohydrate, extra pure, 99% 500GR
