Zibotentan (ZD4054)

186497-07-4

CAS-Nr.: 186497-07-4

Englisch Name:: Zibotentan (ZD4054)

Synonyma:: ZD454;Zd4054;CS-558;Zd 4054;Zibotentan;Zibotentan(ZD4054);zibotentan,CID 9910224;ZD4054;ZD-4054;ZD 4054;Zibotentan >=98% (HPLC);ZIBOTENTAN (ZD4054) 250MG

CBNumber:: CB31475871

Summenformel:: C19H16N6O4S

Molgewicht:: 424.43

MOL-Datei:: 186497-07-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 86

Zibotentan (ZD4054) Eigenschaften

Schmelzpunkt:: 239 - 241°C

Siedepunkt:: 637.0±65.0 °C(Predicted)

Dichte: 1.422

storage temp.: Sealed in dry,Store in freezer, under -20°C

L?slichkeit: DMSO (Sparingly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 5.62±0.40(Predicted)

Farbe: White to Off-White

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitssch?dlich bei Verschlucken.	Akute Toxizit?t oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

Zibotentan (ZD4054) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC₅₀s = 21 and >10,000 nM for human recombinant ET_A and ET_B, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1; ) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2, mediators of cell invasion and angiogenesis, in HEY cells. In vivo, zibotentan (10-50 mg/kg per day) reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner. Formulations containing zibotentan are under clinical investigation for the treatment of ovarian and castration-resistant prostate cancers.

Verwenden

Zibotentan is a specific endothelin-A receptor antagonist that is a potential candidate in the treatment of prostate cancer, bone metastasis and various other types of cancer.

Zibotentan (ZD4054) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Zibotentan (ZD4054) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 86)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22784	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58

N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-[4-(1,3,4-OXADIAZOL-2-YL)PHENYL]PYRIDINE-3-SULFONAMIDE
3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-
Zd 4054
Zd4054
Zibotentan
Zibotentan(ZD4054)
N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-Methoxy-5-Methylpyrazin-2-yl)pyridine-3-sulfonaMide
ZD454
ZIBOTENTAN (ZD4054);ZD4054;ZD-4054;ZD 4054
ZIBOTENTAN (ZD4054) 250MG
zibotentan,CID 9910224
ZD4054;ZD-4054;ZD 4054
CS-558
3-Pyridinesulfonamide, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-
Zibotentan >=98% (HPLC)
Zibotentan (ZD4054) USP/EP/BP
Zibotentan ZD4054 ZD-4054
186497-07-4
C19H16N6O4S
Inhibitors

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