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Psoralens

Psoralens Struktur
CAS-Nr.
Englisch Name:
Psoralens
Synonyma:
Psoralens
CBNumber:
CB31306171
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Psoralens Eigenschaften

Sicherheit

Psoralens Chemische Eigenschaften,Einsatz,Produktion Methoden

Indications

Psoralens form covalent linkages with pyrimidine bases in DNA when exposed to light of the appropriate wavelength, and if oxygen is present, reactive oxygen species also are generated. Although inhibition of DNA replication may account for some of the beneficial effects of PUVA therapy in certain hyperproliferative disorders such as psoriasis, PUVA has other important biological effects.

Pharmakologie

Orally administered psoralens are rapidly absorbed (maximum photosensitivity for the most common preparation, 8-methoxypsoralen [Oxsoralen Ultra], is 1–1.5 hours). Although the elimination half-life is 2.2 hours, the skin remains photosensitive for 8 to 12 hours. Most excretion is renal, and the drug does not accumulate. It can be absorbed if applied topically, and after application to the entire body, therapeutic plasma levels can be detected.

Clinical Use

It suppresses contact hypersensitivity and may evoke other immunological changes by affecting T lymphocytes and epidermal Langerhans cells. It increases melanin pigmentation in the skin and is useful in treating vitiligo. PUVA also inhibits mast cell release of inflammatory mediators.

Psoralens Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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