4-Chlor-4'-fluorbutyrophenon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

slightly yellow-greenish clear oil

Verwenden

4-Chloro-4''-fluorobutyrophenone (cas# 3874-54-2) is a compound useful in organic synthesis.

Verwenden

4-Chloro-4‘-fluorobutyrophenone is a pharmaceutical intermediate compound suitable for the production of antipsychotics and active pharmaceutical ingredients (APIs) for the treatment of depression.4-Chloro-4’-fluorobutyrophenone can be used as a synthesis of trifluprednis, azaperone, melperone, Melperone, Timiperone, Bromoperidol, Haloperidol, Benzoperidol, Droperidol, Fluanisone and other APIs as pharmaceutical intermediates.

Synthese

The purified alkyne (5 mmol) was treated with a solution of HNTf2 (60-200 mol %) in 1,4-dioxane in apreheated oil bath at 100°C, under magnetic stirring, for 18-52 h, and the corresponding ketone was purified by column chromatography after cooling 4-Chloro-4'-fluorobutyrophenone. The reaction crude was purified by column chromatography using 20% AcOEt in n-hexane as an eluent. Isolated yield: 850 mg (85%). R f (20% AcOEt in n-hexane): 0.66. GC-MS (m/ z, M+? 200), major peaks found: 200 (1%), 164 (1%), 138 (43%), 123 (100%), 107 (10%). 1H NMR (δ, ppm; J, Hz): 8.03-7.97 (2C-H arom, mult), 7.17-7.09 (2C-H arom, mult), 3.68 (CH2, t, J = 6.2), 3.15 (CH2, t, J = 7.0), 2.22 (CH2, tt, J = 7.0, 6.2). 13C NMR (δ, ppm; J, Hz): 197.3 (C=O), 166.1 (C, d, J 1 C-F = 254.7), 133.2 (C, d, J 4 C-F = 4.3), 130.6 (2CH, d, J 3 C-F = 9.3), 115.9 (2CH, d, J 2 C-F = 22.2), 44.6 (CH2), 35.2 (CH2), 26.7 (CH2).

4-Chlor-4'-fluorbutyrophenon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-Chlor-4'-fluorbutyrophenon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Famo Biotech Co Ltd	+86-36680037 +86-18550473860	mayan@famobiotech.com;sales@famobiotech.com	China	528	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3958	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3106	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20288	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18648	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58

3874-54-2(4-Chlor-4'-fluorbutyrophenon)Verwandte Suche:

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• 3-CHLOROPROPYL4-FLUOROPHENYLKETONE/4-CHLORO-4''-FLUOROBUTYROPHENONE
• 1-Butanone, 4-chloro-1-(4-fluorophenyl)-
• 1-(4-Fluorophenyl)-4-chloro-1-butanone
• γ-Chloro-4'-fluorobutyrophenone
• ω-Chloro-4'-fluorobutyrophenone
• Chloro-4'-fluorobutyrophe
• 4-Chloro-4'-fluorobu
• 4-chloro-4-fluorophenyl ketone
• 1-Chloro-4-(4-fluorophenyl)-4-oxobutane
• 3-(4-Fluorophenylcarbonyl)-1-chloropropane
• NSC 87082
• 4-Chloro-4'-fluoro-butyrophenone (OR)
• 3-(4-Fluorobenzoyl)propyl chloride
• 3-(p-Fluorobenzoyl)propyl chloride
• GAMMA-CHLORO-4-FLUOROBUTYROPHENONE
• GAMMA-CHLORO-P-FLUOROBUTYROPHENONE
• G-CHLORO-P-FLUOROBUTYROPHENONE
• AKOS BBS-00006481
• 4-CHLORO-1-(4-FLUOROPHENYL)-1-BUTANONE
• 4-CHLORO-1-(4-FLUOROPHENYL)-1-OXOBUTANE
• 4-CHLORO-4'-FLUOROBUTYROPHENONE
• 3-CHLOROPROPYL 4-FLUOROPHENYL KETONE
• TIMTEC-BB SBB003536
• 3-Chloro-4'-fluorobutyrophenone
• 4-(4-Fluorophenyl)-4-oxobutyl chloride
• 4-(p-Fluorophenyl)-4-oxobutyl chloride
• 4-chloro-1-(4-fluorophenyl)-1-butanon
• 4-Chloro-p-fluorobutyrophenone
• 4-Fluorobenzoylpropyl chloride
• Butyrophenone, 4-chloro-4'-fluoro-
• omega-Chloro-4-fluorobutyrophenone
• omega-Chloro-p-fluorobutyrophenone
• p-Fluoro-4-chlorobutyrophenone
• p-Fluorobenzoylpropyl chloride
• p-Fluoro-gamma-chlorobutyrophenone
• p-Fluoro-omega-chlorobutyrophenone
• Chloropfluorobutyrophenone
• OMEGA-CHLORO-4-FLUOROBUTYROPHENONE 97&
• 4-Chloro-4'-fluorobutyrophenone 97%
• 4-Chloro-4'-fluorobutyrophenone97%
• 4-CHLORO-4"-FLUOROBURYROPHENONE
• LUMAT-009
• 4-Cloro-4'-fluorobutirrofenone
• 4-CHLORO-4'-FLUOROBUTYROPHENONE BATCH NO: CFKT-10923/0319/FP/001
• 4-Chloro-4’-fluoro-butyrophenone (OR) 3-Chloropropyl-4-fluorophenyl ketone
• JACS-3874-54-2
• 4-Chloro-4'-fluorobutyrophenone >
• uorobutyrophenone
• Haloperidol Impurity 1
• Haloperidol Decanoate Impurity 17
• 99% Purity 4-Chloro-4'-fluorobutyrophenone
• High Quality 4-Chloro-4'-fluorobutyrophenone
• 4-chloro-4 '-flubutanone
• 4-Chloro-4'Fluorobutyrophenone (FBP)
• 4-Chloro-4'-fluoroacetophenone
• 4-CHLORO-4-FLUOROBUTYROPHENONE
• Azaperone,Droperidol, Haloperidole,Timiperone
• 4-Chloro-4'-fluorobutyrophenone