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Dimetotiazin

Dimetotiazine Struktur
7456-24-8
CAS-Nr.
7456-24-8
Bezeichnung:
Dimetotiazin
Englisch Name:
Dimetotiazine
Synonyma:
8599RP;Fonazine;Bayer 1483;Dimethodin;Brn 0941549;Dimetiotazine;Dimetotiazine;Dimetothiazine;Dimethiotazine;Dimethothiazine
CBNumber:
CB2875673
Summenformel:
C19H25N3O2S2
Molgewicht:
391.557
MOL-Datei:
7456-24-8.mol

Dimetotiazin Eigenschaften

Siedepunkt:
533.7±60.0 °C(Predicted)
Dichte
1.1822 (rough estimate)
Brechungsindex
1.6560 (estimate)
pka
8.91±0.50(Predicted)

Sicherheit

Dimetotiazin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Migristene,Rhone Poulenc,France,1965

Verwenden

Serotonin inhibitor.

Manufacturing Process

A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc) is heated under reflux for 3 hours with sodium amide (1.5 grams). A solution of 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc) is then added and heating under reflux continued for 4 hours. After cooling the suspension obtained is agitated with water (50 cc) and ether (30 cc). The aqueous layer is separated and the basic products are extracted from the organic phase with 10% hydrochloric acid. The xylene layer is discarded and, after the combined acid solutions have been made alkaline with sodium carbonate, the base is extracted with chloroform. The chloroform solutions are then washed with water and dried over anhydrous potassium carbonate. After evaporation of the solvent under reduced pressure there is obtained a crude resinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl) phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding methanesulfonic acid there is obtained fonazine mesylate.

Dimetotiazin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dimetotiazin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 10)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15319487004
1015@dideu.com China 2128 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38465 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19863 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Watson Biotechnology Co.,Ltd 027-59207879 1972026995 18140587686
sales@3600chem.com China 4675 55
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 19711 58

7456-24-8(Dimetotiazin)Verwandte Suche:


  • Dimetotiazine
  • 10-(2-dimethylaminopropyl)-N,N-dimethyl-phenothiazine-2-sulfonamide: m ethanesulfonic acid
  • 10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide
  • 10H-Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-
  • Dimethiotazine
  • Dimethothiazine
  • Fonazine
  • Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl- (6CI, 7CI, 8CI)
  • Dimetiotazine
  • 8599RP
  • Dimetothiazine
  • N,N-Dimethyl-10-[2-(dimethylamino)propyl]-10H-phenothiazine-2-sulfonamide
  • 13115-40-7 (Monomesylate)
  • 3-Dimethylsulfonamido 10-(2-dimethylaminopropyl)phenothiazine
  • Bayer 1483
  • Brn 0941549
  • Dimethodin
  • Dimethylsulfamido-3-(dimethylamino-2-propyl)-10-phenothiazine
  • Dimetotiazine USP/EP/BP
  • 7456-24-8
  • C20H29N3O5S3
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