SINOVA SL-02580 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (K
d= 21.1 nM; K
i = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.
SINOVA SL-02580 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte