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GSK-3BETA INHIBITOR XII

GSK-3BETA INHIBITOR XII Struktur
601514-19-6
CAS-Nr.
601514-19-6
Englisch Name:
GSK-3BETA INHIBITOR XII
Synonyma:
TWS11;TWS S;TWS119;CS-445;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;GSK-3BETA INHIBITOR XII;GSK-3β Inhibitor, TWS119
CBNumber:
CB2803764
Summenformel:
C18H14N4O2
Molgewicht:
318.33
MOL-Datei:
601514-19-6.mol

GSK-3BETA INHIBITOR XII Eigenschaften

Schmelzpunkt:
249 °C
Dichte
1.42
storage temp. 
2-8°C
L?slichkeit
insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
Aggregatzustand
powder
pka
8.99±0.10(Predicted)
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

GSK-3BETA INHIBITOR XII Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.

Allgemeine Beschreibung

A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).

Biologische Aktivit?t

Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

GSK-3BETA INHIBITOR XII Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


GSK-3BETA INHIBITOR XII Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 133)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd

China 10947 58

  • TWS119
  • GSK-3BETA INHIBITOR XII
  • 3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL
  • OTAVA-BB 7070707013
  • 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate
  • 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119
  • TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
  • GSK-3β Inhibitor, TWS119
  • TWS119, >=98%
  • TWS11
  • GSK-3β Inhibitor XII, TWS119
  • CS-1924
  • TWS-119; TWS 119
  • CS-445
  • TWS 119 (This product is unavailable in the U.S.)
  • TWS S
  • Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
  • GSK-3BETA INHIBITOR XII USP/EP/BP
  • 601514-19-6
  • C18H14N4O22CF3CO2H
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
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