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Isoginkgetin

Isoginkgetin Struktur
548-19-6
CAS-Nr.
548-19-6
Englisch Name:
Isoginkgetin
Synonyma:
ISOGINKGETIN;Isoginkgetin-RM;ISOGINKGETIN(SH);Isoginkgetin, >99%;Isoginkgo diflavone;ISOGINKGETIN(RG)(PLEASE CALL);4',4'''-Dimethylamentoflavone;4',4'''-Dimethoxyamentoflavone;Isoginkgetin, 98%, from Ginkgo biloba L.;5,5'',7,7''-Tetrahydroxy-4',4'''-dimethoxy-3''',8-biflavone
CBNumber:
CB2675231
Summenformel:
C32H22O10
Molgewicht:
566.51
MOL-Datei:
548-19-6.mol

Isoginkgetin Eigenschaften

Schmelzpunkt:
355℃
Siedepunkt:
843.6±65.0 °C(Predicted)
Dichte
1.506
storage temp. 
2-8°C(protect from light)
L?slichkeit
DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
Aggregatzustand
powder
pka
6.16±0.40(Predicted)
Farbe
White-beige
InChIKey
HUOOMAOYXQFIDQ-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(OC)C=C2)OC2=C(C3=CC(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1
LogP
5.240 (est)

Sicherheit

Isoginkgetin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing. Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; ) and LPS by approximately 87 and 90%, respectively. It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; ) and the calcium ionophore A23187 by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM. Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.

Definition

ChEBI: A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metal oproteinase 9 (MMP-9).

Origin

Isoginkgetin (ISO), a member of the biflavonoid family, could promote autophagy in HCC cells and human colon carcinoma cells HCT 116. As a natural compound derived from Ginkgo biloba leaves, ISO possesses anti-tumor and anti-splicing functions. Nevertheless, ISO's low water solubility and poor bioavailability hinder its biomedical application [1].

Allgemeine Beschreibung

A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 μM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 μM for 24 h).

Isoginkgetin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Isoginkgetin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 140)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004
1015@dideu.com China 3942 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58

548-19-6()Verwandte Suche:


  • 2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
  • 2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 4',4'''-Dimethoxyamentoflavone
  • ISOGINKGETIN
  • 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 3''',8-Biflavone, 5,5'',7,7''-tetrahydroxy-4',4'''-dimethoxy-
  • 4',4'''-Dimethylamentoflavone
  • ISOGINKGETIN(RG)(PLEASE CALL)
  • 5,5'',7,7''-Tetrahydroxy-4',4'''-dimethoxy-3''',8-biflavone
  • ISOGINKGETIN(SH)
  • Isoginkgetin, >99%
  • Isoginkgetin, 98%, from Ginkgo biloba L.
  • 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-
  • 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
  • 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
  • Isoginkgo diflavone
  • Isoginkgetin-RM
  • 548-19-6
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