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PS10

PS10 Struktur
1564265-82-2
CAS-Nr.
1564265-82-2
Englisch Name:
PS10
Synonyma:
PS10;PS10,PS-10;2-[(24-Dihydroxyphenyl)sulfonyl]-23-dihydro-1H-isoindole-46-diol;1H-Isoindole-4,6-diol, 2-[(2,4-dihydroxyphenyl)sulfonyl]-2,3-dihydro-
CBNumber:
CB24866400
Summenformel:
C14H13NO6S
Molgewicht:
323.32
MOL-Datei:
1564265-82-2.mol

PS10 Eigenschaften

Siedepunkt:
661.7±65.0 °C(Predicted)
Dichte
1.696±0.06 g/cm3(Predicted)
pka
7.05±0.35(Predicted)
Aggregatzustand
Solid
Farbe
Light yellow to khaki

Sicherheit

PS10 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This novel ATP binding pocket-directed inhibitor (FW = 323.32 g/mol), systematically named 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6- diol, targets all four PDK isoforms, with an IC50 = 0.8 μM and Ki = 0.24 μM for PDK2. Its design is based on structure-guided design, converting a known Hsp90 inhibitor into a series of highly specific PDK inhibitors, substituting a sulfonyl group in place of a carbonyl in the parent compound. This modification results in weak binding to Hsp90 (Ki = 47 μM). PS10 administration (70 mg/kg) to diet-induced obese mice significantly augments PDC activity with reduced phosphorylation in different tissues. Prolonged treatment improves glucose tolerance, with notably lessened hepatic steatosis in a mouse model. Such findings suggest pharmacological targeting of PDK may be useful in controlling glucose and fat levels in obesity and type 2 diabetes.

PS10 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PS10 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 10)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
3003855609@qq.com China 7887 56
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761
486064515@qq.com China 4420 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11974 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507
vip@med-life.cn China 4997 58
RD International Technology Co., Limited 18024082417
market@ubiochem.com China 9266 58
Changzhou Yourui Pharmaceutical Technology Co., Ltd 18168818882 18168818882
877458914@qq.com China 1991 58

  • PS10
  • 2-[(24-Dihydroxyphenyl)sulfonyl]-23-dihydro-1H-isoindole-46-diol
  • PS10,PS-10
  • 1H-Isoindole-4,6-diol, 2-[(2,4-dihydroxyphenyl)sulfonyl]-2,3-dihydro-
  • 1564265-82-2
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