Phenethyl caffeate
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- CAS-Nr.
- 104594-70-9
- Englisch Name:
- Phenethyl caffeate
- Synonyma:
- CAFFEIC ACID PHENETHYL ESTER;CAFFEIC ACID PHENYLETHYL ESTER;PHENETHYL CAFFEATE;Phenylethy caffeate;PHENYLETHYL CAFFEATE;PhenethylCaffeate>Caffeic acid pheneth;2-Phenyethyl caffeate;CAPE,PhenethylCaffeate;Caffeic acid phenethyl
- CBNumber:
- CB2438898
- Summenformel:
- C17H16O4
- Molgewicht:
- 284.31
- MOL-Datei:
- 104594-70-9.mol
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Phenethyl caffeate Eigenschaften
- Schmelzpunkt:
- 127-129℃
- Siedepunkt:
- 498.6±45.0 °C(Predicted)
- Dichte
- 1.266±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.
- pka
- 8.46±0.20(Predicted)
- Aggregatzustand
- White to off-white solid
- Farbe
- off-white
- maximale Wellenl?nge (λmax)
- 323nm(lit.)
- Sensitive
- Light Sensitive
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChIKey
- SWUARLUWKZWEBQ-VQHVLOKHSA-N
- LogP
- 3.734 (est)
- CAS Datenbank
- 104594-70-9(CAS DataBase Reference)
Phenethyl caffeate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Phenylethyl caffeate is one of the allergens of propolis
(bee glue); also contained in poplar-bud secretions.
Chemische Eigenschaften
Off-White Solid
Verwenden
Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also
been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
Biologische Aktivit?t
Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF- κ B activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
Kontakt-Allergie
Capee is one of the allergens of propolis (bee glue). It
is also contained in poplar bud secretions.
Anticancer Research
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is a natural phenolcompound and an active component of propolis from honeybee hives. Torkiet al. (2017)investigated the effect of phosphatidylinositol 3-kinase/AKT/mammaliantarget of rapamycin (PI3K/Akt/mTOR) signaling pathway dual inhibitor, NVP-BEZ235,and CAPE on TNBC cell line (MDA-MB-231), stimulated withtransforming growth factor (TGF)-β1 for 14 days. CAPE in combination with NVP-BEZ235synergistically inhibited cell growth and reduced CXCR4 expression.Also, treatment of MDA-MB-231 cells with CAPE and NVP-BEZ235 time-dependentlyinhibited the expression of p-Forkhead Box O3a (FOXO3a). In a nutshell,these results indicate that tumour metastasis and progression in TNBC cellscan be effectively reduced through the concurrent use of NVP-BEZ235 and CAPE(Torki et al. 2017).
Phenethyl caffeate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Phenethyl caffeate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 406)Lieferanten
104594-70-9()Verwandte Suche:
- Caffeic Acid 2-Phenylethyl Ester
- CAFFEIC ACID PHENETHYLESTER (CAPE)
- CAPE,PhenethylCaffeate
- CAFFEIC ACID PHENETHYL ESTER(CAPE)(P)
- KAFFEESUREPHENYLETHYLESTER
- CAFFEICACIDPHENYLETHERESTER
- 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
- Cafestol Acid Phenethyl Ester
- 3,4 - Caffeic Acid Phenethyl Ester
- Phenethyl 3-(3,4-dihydroxyphenyl)acrylate
- Propolis powder extract
- Caffeic acid phenylethyl ester (Phenethyl caffeate)
- Thecaffeic acid phenethyl ester
- (E)-phenethyl 3-(3,4-dihydroxyphenyl)acrylate
- PHENETHYL CAFFEATE (CAPE)
- 2-Propenoic acid,3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester
- Caffeic acid phenethyl ester, >=98%
- Caffeic acid phenethyl
- CAPE (Caffeic Acid Phenethylester)
- Affeic acid phenethyl ester
- Phenethyl 3-(3,4-dihydroxyphenyl)
- PHENYLETHYL CAFFEATE
- PHENETHYL 3,4-DIHYDROXYCINNAMATE
- PHENETHYL CAFFEATE
- (E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOIC ACID, 2-PHENYLETHYL ESTER
- 2-phenylethyl3-(3,4-dihydroxyphenyl)-2-propenoate
- 3-(3,4-dihydroxyphenyl)-2-propenoicaci2-phenylethylester
- beta-phenylethylcaffeate
- Phenylethy caffeate
- Caffeic acid phenethyl ester, 99%, a protein tyrosine kinase and ornithine decarboxylase inhibitor
- 2-Phenyethyl caffeate
- (E)-3-(3,4-dihydroxyphenyl)-2-propenoic acid (phenylmethyl) ester
- PhenethylCaffeate>
- 3,4-Dihydroxycinnamic Acid Phenethyl Ester
- Caffeic acid pheneth
- 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
- CAFFEIC ACID PHENYLETHYL ESTER
- CAFFEIC ACID PHENETHYL ESTER
- Caffeic Acid Phenethyl Ester(Phenethyl Caffeate)
- 2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
- 104594-70-9
- 15610-29-2
- Gene Regulation and Expression
- Gene Regulation
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- HIV/AIDS/Related Products
- Apoptosis Inducers
- Miscellaneous Natural Products
- Inhibitors
- Tyrosine Kinase Inhibitors
- Cytokine signaling
- 104594-70-9
