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Orlistat

Orlistat Struktur
96829-58-2
CAS-Nr.
96829-58-2
Englisch Name:
Orlistat
Synonyma:
Orlistate;XENICAL;Orlistat Powder;aolisita;Orlipastat, Orlistat;N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER;(S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER;Alisit;CS-836;oristat
CBNumber:
CB2431985
Summenformel:
C29H53NO5
Molgewicht:
495.73
MOL-Datei:
96829-58-2.mol

Orlistat Eigenschaften

Schmelzpunkt:
<50 °C
Siedepunkt:
615.9±30.0 °C(Predicted)
alpha 
D20 -32.0° (c = 1 in chloroform)
Dichte
0.976±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: 19 mg/mL
Aggregatzustand
solid
pka
14.59±0.23(Predicted)
Farbe
white
Merck 
14,6869
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChIKey
AHLBNYSZXLDEJQ-FWEHEUNISA-N
SMILES
C(O[C@H](C[C@H]1[C@H](CCCCCC)C(=O)O1)CCCCCCCCCCC)(=O)[C@H](CC(C)C)NC=O
CAS Datenbank
96829-58-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. OH3167600
HS Code  29322090
Giftige Stoffe Daten 96829-58-2(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H412 Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 3 P273, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Orlistat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Orlistat was launched in the UK as Xenical for the long-term treatment of obesity, preferably in conjunction with a moderately reduced calorie diet. Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from Streptomyces toxyfncini) and can be obtained either by hydrogenation of lipstatine or by several different synthetic ways involving many steps from ( S ) - rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a result, it prevents the absorption of about one third of the fat contained in food and acts as an effective weight-reducing therapy. The outcomes of several clinical trials involving thousands of obese patients showed that Orlistat promotes a significant weight loss (often between 5 and 10% after one year) and improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio, blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic absorption, the majority of the compound itself being recovered in the feces ; it does not affect other gastrointestinal processes, or the absorption of other rnacronutrients such as carbohydrates and proteins.

Chemische Eigenschaften

Off-White Solid

Verwenden

Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orlistat is a specific lipase inhibitor derived from lipostatin, which is naturally produced by Streptomyces toxytricini. Lipase inhibition induced by orlistat reduces the absorption of dietary fat, thereby contributing to caloric deficit.

Biologische Aktivit?t

Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo .

Orlistat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Orlistat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 732)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hong Kong Excellence Biotechnology Co., Ltd.

ada@sh-teruiop.com China 875 58
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com China 815 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Sigma Audley
+86-15937194204 +86-18126314766
nova@sh-teruiop.com China 493 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 852 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8817 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5858 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Anhui Yiao New Material Technology Co., Ltd
+86-18033737140 +86-17354101231
sales1@hbganmiao.com China 227 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58

96829-58-2()Verwandte Suche:


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