Indapamid
|
|
|
- CAS-Nr.
- 26807-65-8
- Bezeichnung:
- Indapamid
- Englisch Name:
- Indapamide
- Synonyma:
- INDAPAMID;indaflex;Idapamide;ndapamide;N-(4-CHLORO-3-SULFAMOYLBENZAMIDO)-2-METHYLINDOLINE;4-chloro-N-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfaMoylbenzaMide;s1520;lozol;tandix;damide
- CBNumber:
- CB2420420
- Summenformel:
- C16H16ClN3O3S
- Molgewicht:
- 365.83
- MOL-Datei:
- 26807-65-8.mol
|
Indapamid Eigenschaften
- Schmelzpunkt:
- 160-162°C
- Siedepunkt:
- 110.4°C (rough estimate)
- alpha
- -0.8～+0.8°(D/20℃) (c=5, C2H5OH)
- Dichte
- 1.2895 (rough estimate)
- Brechungsindex
- 1.6100 (estimate)
- storage temp.
- -20°C Freezer
- L?slichkeit
- Practically insoluble in water, soluble in ethanol (96 per cent).
- pka
- pKa (25°) 8.8 ± 0.2
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Soluble in ethanol. Insoluble in water
- Merck
- 14,4935
- BCS Class
- 1
- InChIKey
- NDDAHWYSQHTHNT-UHFFFAOYSA-N
- CAS Datenbank
- 26807-65-8(CAS DataBase Reference)
- EPA chemische Informationen
- Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)- (26807-65-8)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
|
|
| RTECS-Nr. |
CV2451200 |
|
|
| HS Code |
2935904000 |
|
|
| Toxizit?t |
LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.; 394-440, 577-635, 272-358 i.v.; >3000 all species orally (Kyncl) |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H362 |
Kann S?uglinge über die Muttermilch sch?digen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
|
|
P201, P260, P263, P264, P270,P308+P313 |
|
| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt w?hrend der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
|
Indapamid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Indapamide is a derivative of benzolsulfonamide and its mechanism of action is analogous to
that of thiazides. It is intended for lowering arterial blood pressure and as an adjuvant drug for
treating edema caused by cardiac insufficiency.
Chemische Eigenschaften
Crystalline Solid
Definition
ChEBI: A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Clinical Use
Indapamide is an effective
diuretic drug when GFR falls below 40 mL/min. The duration of action is approximately 24 hours, with the normal oral adult dosage starting at 2.5 mg given each morning.
The dose may be increased to 5.0 mg/day, but doses beyond this level do not appear to provide additional results.
Nebenwirkungen
Effects on urine content and side effects are similar to
effects induced by thiazide diuretics.
Indapamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Indapamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 453)Lieferanten
26807-65-8(Indapamid)Verwandte Suche:
- N-[4-CHLORO-3-SULFAMOYL-BENZAMIDOL]-2-METHYLINDOLINE
- INDAPAMIDE
- 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamid
- 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)benzamide
- 4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoyl-benzamid
- natrilix
- noranat
- s1520
- se-1520
- tandix
- IndapaMide(Lozol)
- IndapaMide API
- indaparnide
- 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline
- 4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide
- bajaten
- damide
- fludex
- indamol
- ipamix
- lozol
- IndapamideC16H16C1N303S
- 4-Chloro-N-(2-methyl-1-indolymyl)-3-sulfamolybenzamide
- Arifon
- Flubest
- Idamide
- rac Indapamide
- Veroxil
- Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-
- INDAPAMIDE USP
- Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl- (8CI)
- Fludin
- Flupamid
- Indamide
- Racemic indapamide
- Tertensif
- Indapamidum
- Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-
- Lonzol
- Cormil
- Indapamide (250 mg)
- 1-(4-CHLORO-3-SULFAMOYLBENAZMIDO)-2-METHYL INDOLINE
- Levetiracetam Solution, 100ppm
- 3-(aminosulfonyl)-4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)benzamide
- Indapamide RS
- Indapamide, racemic mixture
- Indapamide CRS
- Indapamide USP/EP/BP
- 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-
sulfamoylbenzamide
- Indapamide(I0150000)Q: What is
Indapamide(I0150000) Q: What is the CAS Number of
Indapamide(I0150000)
- IndapamideQ: What is
Indapamide Q: What is the CAS Number of
Indapamide Q: What is the storage condition of
Indapamide Q: What are the applications of
Indapamide
- Indapamide 13C D3Q: What is
Indapamide 13C D3 Q: What is the CAS Number of
Indapamide 13C D3 Q: What is the storage condition of
Indapamide 13C D3 Q: What are the applications of
Indapamide 13C D3
- (R)-1-"3 , 5-bis(trifluoromethyl)phenyl”ethanol ,TFM
- indaflex
- Idapamide
- INDAPAMID
- ndapamide
- 4-chloro-N-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfaMoylbenzaMide
